Evaluation of Antimicrobial, Anti-Inflammatory and Wound Healing Potentiality of Various Indian Small Herbs: A Meta Analysis

Ajay Kumar; Soma Chowdhury; Reshmi Mukherjee; Angana Naskar; Tushar Singhal; Devinder Kumar; Anurag Chourasia; Vikrant Kumar

doi:10.55544/jrasb.1.3.4

Authors

Ajay Kumar Research Scholar, Department of Zoology, DSB Campus Kumaun University, Nainital, INDIA.
Soma Chowdhury Asst. Professor, Department of Pharmacognosy, Secom Pharmacy College, Dhulagor, Howrah, West Bengal, INDIA.
Reshmi Mukherjee M. Pharm, Department of Pharmaceutical Chemistry, Netaji Subhas Chandra Bose Institute of Pharmacy, Nadia, West Bengal, INDIA.
Angana Naskar Asst. Professor, Department of Pharmacology, Secom Pharmacy College, Dhulagor, Howrah, West Bengal, INDIA.
Tushar Singhal Senior Clinical Researcher, Department of Clinical Research, MAX Healthcare Dehradun, Uttarakhand, INDIA.
Devinder Kumar Asst. Professor, Department of Pharmacology, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Punjab, INDIA.
Anurag Chourasia Asst. Professor, Ramanand Institute of Pharmacy and Management, Haridwar, INDIA.
Vikrant Kumar Department of Pharmacy, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun-248007, Uttarakhand, INDIA.

DOI:

https://doi.org/10.55544/jrasb.1.3.4

Keywords:

Immune system, inflammatory diseases, healing, anti microbial

Abstract

The immune system has the ability to provoke inflammation in response to a wide variety of different triggers. Toxic chemicals, infectious diseases, radiation, and cells that have been harmed are some examples of these stimuli. It removes the detrimental stimuli and at the same time initiates the healing process, which is a win-win situation. As a result, the protective reaction of inflammation is essential for ensuring that the body continues to function properly. The majority of the time, cellular and molecular activities and interactions work together to successfully minimise the risk of experiencing damage or infection during acute inflammatory reactions. This is because these activities and interactions are coordinated to function together. This review article was prepared utilising materials written in English, and it has been published in time intervals of 15 years beginning in 1995 and continuing all the way up until the current day. Both systematic reviews and randomised controlled trials (RCTs), which are considered to be the two most reliable types of research, were included in the collection of publications that were pertinent to the goal that we set for ourselves. The first two approaches are the only ones that should be prioritised above the others. Studies with an open label and studies with cohorts are not as essential as those with a case-control design, which are called preclinical trials.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Awuchi, C. G., Amagwula, I. O., Priya, P., Kumar, R., Yezdani, U., & Khan, M. G. (2020). Aflatoxins in foods and feeds: A review on health implications, detection, and control. Bull. Environ. Pharmacol. Life Sci, 9, 149-155.

Lipsky B. A., Berendt A. R., Cornia P. B., et al. 2012 infectious diseases society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clinical Infectious Diseases. 2012;54(12):e132–e173. doi: 10.1093/cid/cis346.

Umama, Y., Venkatajah, G., Shourabh, R., Kumar, R., Verma, A., Kumar, A., & Gayoor, M. K. (2019). Topic-The scenario of pharmaceuticals and development of microwave as; sisted extraction technique. World J Pharm Pharm Sci, 8(7), 1260-1271.

Cho N. H., Shaw J. E., Karuranga S., et al. IDF Diabetes Atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Research and Clinical Practice. 2018;138:271–281. doi: 10.1016/j.diabres.2018.02.023.

Kumar, R., Saha, P., Lokare, P., Datta, K., Selvakumar, P., & Chourasia, A. (2022). A Systemic Review of Ocimum sanctum (Tulsi): Morphological Characteristics, Phytoconstituents and Therapeutic Applications. International Journal for Research in Applied Sciences and Biotechnology, 9(2), 221-226.

Rodero M. P., Khosrotehrani K. Skin wound healing modulation by macrophages. International Journal of Clinical and Experimental Pathology. 2010;3(7):643–653.

Roshan, K. (2020). Priya damwani, Shivam kumar, Adarsh suman, Suthar Usha. An overview on health benefits and risk factor associated with coffee. International Journal Research and Analytical Review, 7(2), 237-249.

Mirza R. E., Fang M. M., Weinheimer-Haus E. M., Ennis W. J., Koh T. J. Sustained inflammasome activity in macrophages impairs wound healing in type 2 diabetic humans and mice. Diabetes. 2014;63(3):1103–1114. doi: 10.2337/db13-0927.

Sahana, S. (2020). Purabi saha, Roshan kumar, Pradipta das, Indranil Chatterjee, Prasit Roy, Sk Abdur Rahamat. A Review of the 2019 Corona virus (COVID-19) World Journal of Pharmacy and Pharmaceutical science, 9(9), 2367-2381.

Zhao G., Usui M. L., Underwood R. A., et al. Time course study of delayed wound healing in a biofilm-challenged diabetic mouse model. Wound Repair and Regeneration. 2012;20(3):342–352. doi: 10.1111/j.1524-475x.2012.00793.x.

Bind, A., Das, S., Singh, V. D., Kumar, R., Chourasia, A., & Saha, P. Natural Bioactives For The Potential Management Of Gastric Ulceration. Turkish Journal of Physiotherapy and Rehabilitation, 32(3).

Dowd S. E., Wolcott R. D., Sun Y., McKeehan T., Smith E., Rhoads D. Polymicrobial nature of chronic diabetic foot ulcer biofilm infections determined using bacterial tag encoded FLX amplicon pyrosequencing (bTEFAP) PLoS One. 2008;3(10) doi: 10.1371/journal.pone.0003326.e3326

Dubey, A., Yadav, P., Verma, P., & Kumar, R. (2022). Investigation of Proapoptotic Potential of Ipomoea carnea Leaf Extract on Breast Cancer Cell Line. Journal of Drug Delivery and Therapeutics, 12(1), 51-55.

Malone M., Johani K., Jensen S. O., et al. Next generation DNA sequencing of tissues from infected diabetic foot ulcers. EBioMedicine. 2017;21:142–149. doi: 10.1016/j.ebiom.2017.06.026

Kumar, R., & Dubey, A. PHYTOCHEMICAL INVESTICATION AND HEPTOPROTECTIVE EVALUTION ACACIA RUBICA EXTRACT ISONIZED AND PARACETAMOL INDUSED ANIMAL TOXICITY. Turkish Journal of Physiotherapy and Rehabilitation, 32(3).

Dunyach-Remy C., Ngba Essebe C., Sotto A., Lavigne J.-P. Staphylococcus aureus toxins and diabetic foot ulcers: role in pathogenesis and interest in diagnosis. Toxins. 2016;8(7):p. 209. doi: 10.3390/toxins8070209

Saha, P., Kumar, R., Nyarko, R. O., Kahwa, I., & Owusu, P. (2021). HERBAL SECONDARY METABOLITE FOR GASTRO-PROTECTIVE ULCER ACTIVITY WITH API STRUCTURES.

Rao P. Bhaishajya Kalpana Vijnanam. Varanasi, India: Chaukhamba Publications; 2013. pp. 250–274.

Nyarko, R. O., Prakash, A., Kumar, N., Saha, P., & Kumar, R. (2021). Tuberculosis a globalized disease. Asian Journal of Pharmaceutical Research and Development, 9(1), 198-201.

Raj, A., Tyagi, S., Kumar, R., Dubey, A., & Hourasia, A. C. (2021). Effect of isoproterenol and thyroxine in herbal drug used as cardiac hypertrophy. Journal of Cardiovascular Disease Research, 204-217

Kumar B., Vijayakumar M., Govindarajan R., Pushpangadan P. Ethnopharmacological approaches to wound healing-exploring medicinal plants of India. Journal of Ethnopharmacology. 2007;114(2):103–113. doi: 10.1016/j.jep.2007.08.010.

Singh, M. K., Kumar, A., Kumar, R., Kumar, P. S., Selvakumar, P., & Chourasia, A. (2022). Effects of Repeated Deep Frying on Refractive Index and Peroxide Value of Selected Vegetable Oils. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 28-31.

Kumar M. Jaatyadi Ghrita and its use in treating vrana (wound) International Research Journal of Pharmacy. 2014;5(3):128–130. doi: 10.7897/2230-8407.050327.

Sahana, S. (2020). Roshan kumar, Sourav nag, Reshmi paul, Nilayan guha, Indranil Chatterjee. A Review on Alzheimer disease and future prospects. World Journal of Pharmacy and Pharmaceutical science, 9(9), 1276-1285.

Kulkarni Y., Emmi S., Dongargaon T., Wali A. Wound healing effect of Vimlāpanakarma with Jātyādi tailam in diabetic foot. Ancient Science of Life. 2015;34(3):171–174. doi: 10.4103/0257-7941.157164.

Singh S., Rajoria K. Ayurvedic management of life-threatening skin emergency erythroderma: a case study. AYU (An International Quarterly Journal of Research in Ayurveda) 2015;36(1):69–72. doi: 10.4103/0974-8520.169015.

Nyarko, R. O., Kumar, R., Sharma, S., Chourasia, A., Roy, A., & Saha, P. (2022). ANTIBACTERIAL ACTIVITY OF HERBAL PLANT-TINOSPORA CORDIFOLIA AND CATHARNTHUS ROSEUS.

Shailajan S., Menon S., Pednekar S., Singh A. Wound healing efficacy of Jatyadi Taila: in vivo evaluation in rat using excision wound model. Journal of Ethnopharmacology. 2011;138(1):99–104. doi: 10.1016/j.jep.2011.08.050.

Sahana, S., Kumar, R., Nag, S., Paul, R., Chatterjee, I., & Guha, N. (2020). A REVIEW ON ALZHEIMER DISEASE AND FUTURE PROSPECTS.

Nyarko, R. O., Saha, P., Kumar, R., Kahwa, I., Boateng, E. A., Boateng, P. O., ... & Bertram, A. (2021). Role of Cytokines and Vaccines in Break through COVID 19 Infections. Journal of Pharmaceutical Research International, 33, 2544-2549.

amadagni P. S., Jamadagni S., Mukherjee K., et al. Experimental and histopathological observation scoring methods for evaluation of wound healing properties of Jatyadi Ghrita. Ayu. 2016;37(3-4):222–229. doi: 10.4103/ayu.ayu_51_17.

PURABISAHA, R. K., RAWAT, S. S. N., & PRAKASH, A. (2021). A REVIEW ON NOVEL DRUG DELIVERY SYSTEM.

Ayyar S. R., Vaidhyaratnam P, Warrier’s S. Kottakal, India: Arya Vaidhya Sala; pp. 97–98

Nyarko, R. O., Boateng, E., Kahwa, I., & Boateng, P. O. (2020). A comparison analysis on remdesivir, favipiravir, hydroxychloroquine, chloroquine and azithromycin in the treatment of corona virus disease 2019 (COVID-19)-A Review. World J. Pharm. Pharm. Sci, 9, 121-133.

Nyarko, R. O., Boateng, E., Kahwa, I., Boateng, P. O., & Asare, B. (2020). The impact on public health and economy using lockdown as a tool against COVID-19 pandemic in Africa: a perspective. J Epidemiol Public Health Rev, 5(3).

Vijakumar B., Rao P. N., Hemant K. P. A Case discussion on Dushta vrana (chronic wound) International Journal of Ayurvedic Medicine. 2012;3(1):53–57.

KUMAR, R., SAHA, P., SARKAR, S., RAWAT, N., & PRAKASH, A. (2021). A REVIEW ON NOVEL DRUG DELIVERY SYSTEM. IJRAR-International Journal of Research and Analytical Reviews (IJRAR), 8(1), 183-199.

Kumar, R., Saha, P., Pathak, P., Mukherjee, R., Kumar, A., & Arya, R. K. EVOLUTION OF TOLBUTAMIDE IN THE TREATMENT OF DIABETES MELLITUS. Jour. of Med. P’ceutical & Alli. Sci, 9.

Pharmacopoeia of India (API) Part I. 1st. New Delhi, India: Government of India, Ministry of Health and Family Welfare, Department of AYUSH; 2008. pp. 33–34.

Kumar, R., Saha, P., Kumar, Y., Sahana, S., Dubey, A., & Prakash, O. (2020). A Review on Diabetes Mellitus: Type1 & Type2. World Journal of Pharmacy and Pharmaceutical Sciences, 9(10), 838-850.

Evance W. C. Trease and Evans’ Pharmacognosy. 14th. San Diego, CA, USA: Harcourt, Brace; 1997. pp. 96–98

Daharia, A., Jaiswal, V. K., Royal, K. P., Sharma, H., Joginath, A. K., Kumar, R., & Saha, P. (2022). A Comparative review on ginger and garlic with their pharmacological Action. Asian Journal of Pharmaceutical Research and Development, 10(3), 65-69.

Balouiri M., Sadiki M., Ibnsouda S. K. Methods for in vitro evaluating antimicrobial activity: a review. Journal of Pharmaceutical Analysis. 2016;6(2):71–79. doi: 10.1016/j.jpha.2015.11.005.

Kumar, R., Jain, A., Tripathi, A. K., & Tyagi, S. (2021, January). Covid-19 outbreak: An epidemic analysis using time series prediction model. In 2021 11th international conference on cloud computing, data science & engineering (Confluence) (pp. 1090-1094). IEEE.

Yang Y., Zhang Z., Li S., Ye X., Li X., He K. Synergy effects of herb extracts: pharmacokinetics and pharmacodynamic basis. Fitoterapia. 2014;92(2):133–147. doi: 10.1016/j.fitote.2013.10.010.

Dhande P. P., Raj S., Kureshee N. I., et al. Burn wound healing potential of Jatyadi formulations in rats. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2012;3(4):747–754.

KUMAR, A. (2019). The Scenario of Pharmaceuticals and Development of Microwave Assisted Extraction Techniques.

Aarestrup F. M., Hasman H. Susceptibility of different bacterial species isolated from food animals to copper sulfate, zinc chloride and antimicrobial substances used for disinfection. Veterinary Microbiology. 2004;100(1-2):83–89. doi: 10.1016/j.vetmic.2004.01.013

Saha, P., Nyarko, R. O., Lokare, P., Kahwa, I., Boateng, P. O., & Asum, C. (2022). Effect of Covid-19 in Management of Lung Cancer Disease: A Review. Asian Journal of Pharmaceutical Research and Development, 10(3), 58-64.

Sen C. K., Khanna S., Venojarvi M., et al. Copper-induced vascular endothelial growth factor expression and wound healing. American Journal of Physiology-Heart and Circulatory Physiology. 2002;282(5):p. H1821.

Kumar, R., & Saha, P. (2022). A Review on Artificial Intelligence and Machine Learning to Improve Cancer Management and Drug Discovery. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 149-156.

Smith K., Collier A., Townsend E. M., et al. One step closer to understanding the role of bacteria in diabetic foot ulcers: characterising the microbiome of ulcers. BMC Microbiology. 2016;16(1):p. 54. doi: 10.1186/s12866-016-0665-z.

Kumar, S., Yadav, S. P., Chandra, G., Sahu, D. S., Kumar, R., Maurya, P. S., ... & Ranjan, K. (2019). Effect of dietary supplementation of yeast (Saccharomyces cerevisiae) on performance and hemato-biochemical status of broilers.

Xavier W., Sukumaran M. T., Varma A. K., et al. Emergence of multi drug resistant bacteria in diabetic patients with lower limb wounds. Indian Journal of Medical Research. 2014;140(3):435–437.

Mayankesh Pandey, Akanksha Singh, Namrata, Nidhee Agnihotri, Roshan Kumar, Purabi Saha, Ravi Pratap Pandey, Amit Kumar, & Shiwangi. (2022). Clinical Pharmacology & Therapeutic uses of Diuretic Agents: A Review. Journal for Research in Applied Sciences and Biotechnology, 1(3), 11–20. https://doi.org/10.55544/jrasb.1.3.3

Basak D. P., Adhikary T., Das P., Biswas S. Phytochemical analysis and comparative study of antibacterial effect of turmeric extracts using different solvent. IOP Conference Series: Materials Science and Engineering. 2018;410 doi: 10.1088/1757-899x/410/1/012018.012018

Ge Y., MacDonald D., Hait H., et al. Microbiological profile of infected diabetic foot ulcers. Diabetic Medicine. 2002;19(12):1032–1034.

Mukkamala, R., Kumar, R., Banerjee, S. K., & Aidhen, I. S. (2020). Synthesis of Benzyl C‐Analogues of Dapagliflozin as Potential SGLT2 Inhibitors. European Journal of Organic Chemistry, 2020(12), 1828-1839.

Gardner S. E., Hillis S. L., Heilmann K., Segre J. A., Grice E. A. The neuropathic diabetic foot ulcer microbiome is associated with clinical factors. Diabetes. 2013;62(3):923–930. doi: 10.2337/db12-0771.

Schierle C. F., De la Garza M., Mustoe T. A., Galiano R. D. Staphylococcal biofilms impair wound healing by delaying reepithelialization in a murine cutaneous wound model. Wound Repair and Regeneration. 2009;17(3):354–359. doi: 10.1111/j.1524-475x.2009.00489.x

Bhati, V., Yadav, P. K., & Kumar, R. (2018). Effect of Levels of Inorganic Fertilizers, Organic Manure and Bio-Fertilizers on Plant Growth Attributes of Onion (Allium cepa L.) cv. N-53 under Hot Arid Region of Western Rajasthan, India. International J. Curr. Micro. Appl. Sci, 7, 3593-601.

Rex J. R. S., Muthukumar N. M. S. A., Selvakumar P. M. Phytochemicals as a potential source for anti-microbial, anti-oxidant and wound healing - a review. MOJ Bioorganic & Organic Chemistry. 2018;2(2):61–70. doi: 10.15406/mojboc.2.

Nyarko, R. O., Roopini, R., Raviteja, V., Awuchi, C. G., Kumar, R., Faller, E. M., ... & Saha, P. (2022). Novel Sars-CoV-2 Variants & Therapeutic Effects. Journal for Research in Applied Sciences and Biotechnology, 1(2), 25-34.

Negi P. S., Jayaprakasha G. K., Sakariah K. K. Antibacterial activity of turmeric oil: a byproduct from curcumin manufacture. Journal of Agricultural and Food Chemistry. 1999;47(10):4297–4300. doi: 10.1021/jf990308d.

Kumar, R., Keshamma, E., Paswan, S. K., Saha, P., Trivedi, U., Chourasia, A., & Otia, M. (2022). Alkaloid Based Chemical Constituents of Ocimum santum & Cinchona Bark: A Meta Analysis. Journal for Research in Applied Sciences and Biotechnology, 1(2), 35-42.

Singh R., Chandra R., Bose M., et al. Antibacterial activity of Curcuma longa rhizome extract on pathogenic bacteria. Current Science. 2002;83(6):737–740.

Czernicka L., Grzegorczyk A., Marzec Z., Antosiewicz B., Malm A., Kukula-Koch W. Antimicrobial potential of single metabolites of Curcuma longa assessed in the total extract by thin-layer chromatography-based bioautography and image analysis. International Journal of Molecular Sciences. 2019;20(4):p. 898. doi: 10.3390/ijms20040898.

Singh, Y., Paswan, S. K., Kumar, R., Otia, M. K., Acharya, S., Kumar, D., & Keshamma, E. (2022). Plant & Its Derivative Shows Therapeutic Activity on Neuroprotective Effect. Journal for Research in Applied Sciences and Biotechnology, 1(2), 10-24.

Li C., Xi F., Mi J., et al. Two new 3,4;9,10-secocycloartane type triterpenoids from Illicium difengpi and their anti-inflammatory activities. Evidence Based Complementary and Alternative Medicine. 2013;2013:9. doi: 10.1155/2013/942541.942541

Sanchez-Quesada C., Lopez-Biedma A., Toledo E., et al. Squalene Stimulates a Key innate immune cell to Foster wound healing and Tissue repair. Evidence Based Complementary and Alternative Medicine. 2018;2018 doi: 10.1155/2018/9473094.9473094

Saha, P., Kumar, A., Bhanja, J., Shaik, R., Kawale, A. L., & Kumar, R. (2022). A Review of Immune Blockade Safety and Antitumor Activity of Dostarlimab Therapy in Endometrial Cancer. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 201-209.

Navarro A., De las Heras B., Villar A. Anti-inflammatory and immunomodulating properties of a sterol fraction from Sideritis foetens. Biological and Pharmaceutical Bulletin. 2011;24(5):470–473.

Kumar, R., Keshamma, E., Paswan, S. K., Saha, P., Trivedi, U., Chourasia, A., & Otia, M. (2022). Alkaloid Based Chemical Constituents of Ocimum santum & Cinchona Bark: A Meta Analysis. Journal for Research in Applied Sciences and Biotechnology, 1(2), 35-42.

Silva R. O., Sousa F. B. M., Damasceno S. R. B., et al. Phytol, a diterpene alcohol, inhibits the inflammatory response by reducing cytokine production and oxidative stress. Fundamental & Clinical Pharmacology. 2014;28(4):455–464. doi: 10.1111/fcp.12049.

Islam M. T., Ayatollahi S. A., Zihad S. M. N. K., et al. Phytol anti-inflammatory activity: pre-clinical assessment and possible mechanism of action elucidation. Cellular and Molecular Biology. 2020;66(4):264–269. doi: 10.14715/cmb/2020.66.4.31.

Yoon B., Jackman J., Valle-González E., Cho N.-J. Antibacterial free fatty acids and monoglycerides: biological activities, experimental testing, and therapeutic applications. International Journal of Molecular Sciences. 2018;19(4):p. 1114. doi: 10.3390/ijms19041114.