Plant & Its Derivative Shows Therapeutic Activity on Neuroprotective Effect

Yogendra Singh; Shravan Kumar Paswan; Roshan Kumar; Mihir Kedarbhai Otia; Smita Acharya; Devinder Kumar; Keshamma E.

doi:10.55544/jrasb.1.2.2

Authors

Dr. Yogendra Singh Director, School of Pharmacy, Maharaja Agrasen University, Baddi, Himachal Pradesh, INDIA.
Shravan Kumar Paswan Senior Research Fellow, All India Institute of Medical Sciences (AIIMS), New Delhi-110029, INDIA.
Roshan Kumar Research Scholar, Department of Pharmacology, Dev Bhoomi Institute of Pharmacy and Research, Dehradun, Uttarakhand, INDIA.
Mihir Kedarbhai Otia Pharmaceutical Technology, Babaria Institute of Pharmacy, Vadodara, Gujarat Technological University, Gujarat, INDIA.
Smita Acharya PG Scholar, Alwar Pharmacy College, Alwar, Rajasthan, INDIA.
Devinder Kumar Asst. Professor, Department of Pharmacology, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Punjab, INDIA.
Dr. Keshamma E. Associate Professor, Department of Biochemistry, Maharani Cluster University, Palace Road, Bangalore – 560001, INDIA.

DOI:

https://doi.org/10.55544/jrasb.1.2.2

Keywords:

Herbal Plants, Phyto-chemical Study, Neuro-disease, Parkinson disease, Alzheimer disease

Abstract

In most cases, the death of neurons in certain parts of the brain is the defining feature of a condition that is classified as neurodegenerative. There have been studies conducted on both conventional and innovative drugs, however the results have shown that they only offer symptomatic advantages and come with a number of undesirable side effects. The finding of more potent compounds that can stop the pathophysiology of these diseases will be seen as a miracle in the present day. There is a wide variety of synthetic compounds accessible; nevertheless, these drugs may also create a broad range of additional health issues. As a consequence of this, scientists are looking to plants and other natural sources for the development of new medicines. In the practise of conventional medicine, it has been discovered that certain plants possess healing powers. The use of phytochemicals, which are produced from medicinal plants, may eventually replace the need for synthetic molecules. Numerous phytochemicals have been shown to be effective in the treatment of a wide range of diseases. This article discusses the potential therapeutic applications of plant-derived alkaloids for a number of neurodegenerative disorders (NDDs), including Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), epilepsy, schizophrenia, and stroke. There are many different types of alkaloids that can be found in the plant kingdom. Some of these alkaloids include isoquinoline, indole, pyrroloindole, oxindole, piperidine, pyridine, aporphine, vinca, -carboline, methylxanthene, lycopodium, and erythrine byproducts. Alkaloids have a beneficial effect on the pathophysiology of these diseases because of their ability to act as muscarinic and adenosine receptor agonists, anti-oxidants, anti-amyloid and MAO inhibitors, acetylcholinestrase and butyrylcholinesterase inhibitors, an inhibitor of synuclein aggregation, dopaminergic and nicotine agonists, and NMDA antagonists.

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