Burn Injury Management, Pathophysiology and Its Future Prospectives

Authors

  • Roshan Kumar Assistant Professor, Guru Nanak College of Pharmaceutical Sciences, Dehradun, Uttarakhand, INDIA.
  • Dr. Keshamma E Associate professor, Department of Biochemistry, Maharani Cluster University, Palace Road, Bangalore – 560001, INDIA.
  • Bhawana Kumari Assistant Professor, Ranchi College of Pharmacy, Prem Nagar, Road No 3, Hatia - 834003, INDIA.
  • Ajay Kumar Research Scholar, Department of Zoology, DSB Campus Kumaun University, Nainital, INDIA.
  • Vikrant Kumar Department of Pharmacy, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun-248007, Uttarakhand, INDIA.
  • Deepika Janjua Department of Pharmacy, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun-248007, Uttarakhand, INDIA.
  • A. Mohathasim Billah Professor and Head, Depart. of Pharmacy Practice, MRM College of Pharmacy, Ibrahimpatnam, Hyderabad, Telangana, INDIA.

DOI:

https://doi.org/10.55544/jrasb.1.4.10

Keywords:

Burn, Pathology, wound healing, skin infection

Abstract

For intensive care physicians, burns are a frequent and challenging patient complication. Specialist facilities prioritise patient stabilisation, infection prevention, and functional rehabilitation to the greatest extent possible. Researchers have been focusing on burns for decades, and thanks to their efforts, the mortality rate for burn patients, especially young patients and those with moderate burns, has been steadily declining. However, the intensivist often faces challenges that make it hard to provide care and stabilise patients. There may be unique complications associated with burn wounds that necessitate either delayed treatment or prolonged rehabilitation. Improvements in patient stabilisation and treatment have resulted from advances made in burn wound care thanks to research. This article discusses recent advances in the treatment of burn patients, focusing on the pathophysiology of burns and the management of burn wounds.

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References

Tolles J. Emergency department management of patients with thermal burns. Emerg Med Pract. 2018 Feb;20(2):1-24.

Toussaint J, Singer AJ. The evaluation and management of thermal injuries: 2014 update. Clin Exp Emerg Med. 2014 Sep;1(1):8-18.

Vivó C, Galeiras R, del Caz MD. Initial evaluation and management of the critical burn patient. Med Intensiva. 2016 Jan-Feb;40(1):49-59.

Kumar, R., Saha, P., Lokare, P., Datta, K., Selvakumar, P., & Chourasia, A. (2022). A Systemic Review of Ocimum sanctum (Tulsi): Morphological Characteristics, Phytoconstituents and Therapeutic Applications. International Journal for Research in Applied Sciences and Biotechnology, 9(2), 221-226.

Evers LH, Bhavsar D, Mailänder P. The biology of burn injury. Exp Dermatol. 2010 Sep;19(9):777-83.

Hautier A. [Minor burn outpatient management]. Rev Prat. 2018 Dec;68(10):1083-1086.

Roshan, K. (2020). Priya damwani, Shivam kumar, Adarsh suman, Suthar Usha. An overview on health benefits and risk factor associated with coffee. International Journal Research and Analytical Review, 7(2), 237-249.

Nicolas C, Maréchal O. [Severe burned patient rehabilitation]. Rev Prat. 2018 Dec;68(10):1092-1095

Burnett E, Gawaziuk JP, Shek K, Logsetty S. Healthcare resource utilization associated with burns and necrotizing fasciitis. J. Burn Care Res. 2017;38:e886–e891. doi: 10.1097/BCR.0000000000000513.

Bind, A., Das, S., Singh, V. D., Kumar, R., Chourasia, A., & Saha, P. Natural Bioactives For The Potential Management Of Gastric Ulceration. Turkish Journal of Physiotherapy and Rehabilitation, 32(3).

Enns J, et al. Mental and physical health outcomes in parents of children with burn injuries as compared with matched controls. J. Burn Care Res. 2016;37:e18–e26. doi: 10.1097/BCR.0000000000000309.

Logsetty S, et al. Mental health outcomes of burn: a longitudinal population-based study of adults hospitalized for burns. Burns. 2016;42:738–744. doi: 10.1016/j.burns.2016.03.006.

Mason SA, et al. Increased rate of long-term mortality among burn survivors. Ann. Surg. 2019;269:1192–1199. doi: 10.1097/SLA.0000000000002722.

Sahana, S. (2020). Purabi saha, Roshan kumar, Pradipta das, Indranil Chatterjee, Prasit Roy, Sk Abdur Rahamat. A Review of the 2019 Corona virus (COVID-19) World Journal of Pharmacy and Pharmaceutical science, 9(9), 2367-2381.

National Academies of Sciences, Engineering, and Medicine. A National Trauma Care System: Integrating Military and Civilian Trauma Systems to Achieve Zero Preventable Deaths After Injury (National Academies Press, 2016).

Stone J, et al. Outcomes in adult survivors of childhood burn injuries as compared with matched controls. J. Burn Care Res. 2016;37:e166–e173. doi: 10.1097/BCR.0000000000000323.

Rybarczyk MM, et al. A systematic review of burn injuries in low- and middle-income countries: epidemiology in the WHO-defined African region. Afr. J. Emerg. Med. 2017;7:30–37. doi: 10.1016/j.afjem.2017.01.006.

Nyarko, R. O., Prakash, A., Kumar, N., Saha, P., & Kumar, R. (2021). Tuberculosis a globalized disease. Asian Journal of Pharmaceutical Research and Development, 9(1), 198-201.

Stylianou N, Buchan I, Dunn KW. A review of the international Burn Injury Database (iBID) for England and Wales: descriptive analysis of burn injuries 2003–2011. BMJ Open. 2015;5:e006184. doi: 10.1136/bmjopen-2014-006184.

Sethi J, Gawaziuk JP, Cristall N, Logsetty S. The relationship between income and burn incidence in Winnipeg, Manitoba, Canada: a population health study. J. Burn Care Res. 2018;39:645–651. doi: 10.1093/jbcr/iry017.

Padalko A, Cristall N, Gawaziuk JP, Logsetty S. Social complexity and risk for pediatric burn injury: a systematic review. J. Burn Care Res. 2019;40:478–499. doi: 10.1093/jbcr/irz059.

Saha, P., Kumar, R., Nyarko, R. O., Kahwa, I., & Owusu, P. (2021). HERBAL SECONDARY METABOLITE FOR GASTRO-PROTECTIVE ULCER ACTIVITY WITH API STRUCTURES.

Peck M, Pressman MA. The correlation between burn mortality rates from fire and flame and economic status of countries. Burns. 2013;39:1054–1059. doi: 10.1016/j.burns.2013.04.010.

Spiwak R, Logsetty S, Afifi TO, Sareen J. Severe partner perpetrated burn: examining a nationally representative sample of women in India. Burns. 2015;41:1847–1854. doi: 10.1016/j.burns.2015.08.035.

Sahana, S. (2020). Roshan kumar, Sourav nag, Reshmi paul, Nilayan guha, Indranil Chatterjee. A Review on Alzheimer disease and future prospects. World Journal of Pharmacy and Pharmaceutical science, 9(9), 1276-1285.

Ready FL, et al. Epidemiologic shifts for burn injury in Ethiopia from 2001 to 2016: implications for public health measures. Burns. 2018;44:1839–1843. doi: 10.1016/j.burns.2018.04.005.

World Health Organization. Global Burn Registry.

Smolle C, et al. Recent trends in burn epidemiology worldwide: a systematic review. Burns. 2017;43:249–257. doi: 10.1016/j.burns.2016.08.013.

Greenhalgh DG. Management of burns. N. Engl. J. Med. 2019;380:2349–2359. doi: 10.1056/NEJMra1807442.

Nyarko, R. O., Saha, P., Kumar, R., Kahwa, I., Boateng, E. A., Boateng, P. O., ... & Bertram, A. (2021). Role of Cytokines and Vaccines in Break through COVID 19 Infections. Journal of Pharmaceutical Research International, 33, 2544-2549.

Bayuo J, Agbenorku P, Amankwa R, Agbenorku M. Epidemiology and outcomes of burn injury among older adults in a Ghanaian tertiary hospital. Burns Open. 2018;2:98–103. doi: 10.1016/j.burnso.2017.12.003.

Sanghavi P, Bhalla K, Das V. Fire-related deaths in India in 2001: a retrospective analysis of data. Lancet. 2009;373:1282–1288. doi: 10.1016/S0140-6736(09)60235-X.

Tegtmeyer LC, et al. Retrospective analysis on thermal injuries in children—demographic, etiological and clinical data of German and Austrian pediatric hospitals 2006–2015—approaching the new German burn registry. Burns. 2018;44:150–157. doi: 10.1016/j.burns.2017.05.013.

Nyarko, R. O., Kumar, R., Sharma, S., Chourasia, A., Roy, A., & Saha, P. (2022). ANTIBACTERIAL ACTIVITY OF HERBAL PLANT-TINOSPORA CORDIFOLIA AND CATHARNTHUS ROSEUS.

Dissanaike S, Rahimi M. Epidemiology of burn injuries: highlighting cultural and socio-demographic aspects. Int. Rev. Psychiatry. 2009;21:505–511. doi: 10.3109/09540260903340865.

Atwell K, Bartley C, Cairns B, Charles A. The effect of pre-existing seizure disorders on mortality and hospital length of stay following burn injury. J. Burn Care Res. 2019;40:979–982. doi: 10.1093/jbcr/irz141.

PURABISAHA, R. K., RAWAT, S. S. N., & PRAKASH, A. (2021). A REVIEW ON NOVEL DRUG DELIVERY SYSTEM.

. Kallinen O, Maisniemi K, Böhling T, Tukiainen E, Koljonen V. Multiple organ failure as a cause of death in patients with severe burns. J. Burn Care Res. 2012;33:206–211. doi: 10.1097/BCR.0b013e3182331e73.

Nielson CB, Duethman NC, Howard JM, Moncure M, Wood JG. Burns: pathophysiology of systemic complications and current management. J. Burn Care Res. 2017;38:e469–e481. doi: 10.1097/BCR.0000000000000355.

Osuka A, Ogura H, Ueyama M, Shimazu T, Lederer JA. Immune response to traumatic injury: harmony and discordance of immune system homeostasis. Acute Med. Surg. 2014;1:63–69. doi: 10.1002/ams2.17.

Kumar, R., Saha, P., Kumar, Y., Sahana, S., Dubey, A., & Prakash, O. (2020). A Review on Diabetes Mellitus: Type1 & Type2. World Journal of Pharmacy and Pharmaceutical Sciences, 9(10), 838-850.

Sood RF, et al. Early leukocyte gene expression associated with age, burn size, and inhalation injury in severely burned adults. J. Trauma Acute Care Surg. 2016;80:250–257. doi: 10.1097/TA.0000000000000905.

Xiao W, et al. A genomic storm in critically injured humans. J. Exp. Med. 2011;208:2581–2590. doi: 10.1084/jem.20111354.

Muthu K, et al. Perturbed bone marrow monocyte development following burn injury and sepsis promote hyporesponsive monocytes. J. Burn Care Res. 2008;29:12–21. doi: 10.1097/BCR.0b013e31815fa499.

Nyarko, R. O., Boateng, E., Kahwa, I., Boateng, P. O., & Asare, B. (2020). The impact on public health and economy using lockdown as a tool against COVID-19 pandemic in Africa: a perspective. J Epidemiol Public Health Rev, 5(3).

Rae L, Fidler P, Gibran N. The physiologic basis of burn shock and the need for aggressive fluid resuscitation. Crit. Care Clin. 2016;32:491–505.

Guillory A, Clayton R, Herndon D, Finnerty C. Cardiovascular dysfunction following burn injury: what we have learned from rat and mouse models. Int. J. Mol. Sci. 2016;17:53. doi: 10.3390/ijms17010053.

Kumar, R., Saha, P., Pathak, P., Mukherjee, R., Kumar, A., & Arya, R. K. EVOLUTION OF TOLBUTAMIDE IN THE TREATMENT OF DIABETES MELLITUS. Jour. of Med. P’ceutical & Alli. Sci, 9.

Lorente JA, et al. Systemic hemodynamics, gastric intramucosal PCO2 changes, and outcome in critically ill burn patients. Crit. Care Med. 2000;28:1728–1735. doi: 10.1097/00003246-200006000-00005.

Vaughn L, Beckel N. Severe burn injury, burn shock, and smoke inhalation injury in small animals. Part 1: burn classification and pathophysiology: severe burn injury and smoke inhalation injury. J. Vet. Emerg. Crit. Care. 2012;22:179–186. doi: 10.1111/j.1476-4431.2012.00727.x.

Daharia, A., Jaiswal, V. K., Royal, K. P., Sharma, H., Joginath, A. K., Kumar, R., & Saha, P. (2022). A Comparative review on ginger and garlic with their pharmacological Action. Asian Journal of Pharmaceutical Research and Development, 10(3), 65-69.

Keck M, Herndon DH, Kamolz LP, Frey M, Jeschke MG. Pathophysiology of burns. Wien. Med. Wochenschr. 2009;159:327–336. doi: 10.1007/s10354-009-0651-2.

Brooks NC, et al. XBP-1s is linked to suppressed gluconeogenesis in the ebb phase of burn injury. Mol. Med. 2013;19:72–78. doi: 10.2119/molmed.2012.00348.

Jeschke MG, et al. Calcium and ER stress mediate hepatic apoptosis after burn injury. J. Cell. Mol. Med. 2009;13:1857–1865. doi: 10.1111/j.1582-4934.2008.00644.x.

Saha, P., Nyarko, R. O., Lokare, P., Kahwa, I., Boateng, P. O., & Asum, C. (2022). Effect of Covid-19 in Management of Lung Cancer Disease: A Review. Asian Journal of Pharmaceutical Research and Development, 10(3), 58-64.

Jeschke MG. The hepatic response to thermal injury: is the liver important for postburn outcomes? Mol. Med. 2009;15:337–351. doi: 10.2119/molmed.2009.00005.

Jeschke MG. Postburn hypermetabolism: past, present, and future. J. Burn Care Res. 2016;37:86–96. doi: 10.1097/BCR.0000000000000265.

Sidossis LS, et al. Browning of subcutaneous white adipose tissue in humans after severe adrenergic stress. Cell Metab. 2015;22:219–227. doi: 10.1016/j.cmet.2015.06.022.

Kumar, R., Jain, A., Tripathi, A. K., & Tyagi, S. (2021, January). Covid-19 outbreak: An epidemic analysis using time series prediction model. In 2021 11th international conference on cloud computing, data science & engineering (Confluence) (pp. 1090-1094). IEEE.

Gore DC, et al. Hyperglycemia exacerbates muscle protein catabolism in burn-injured patients. Crit. Care Med. 2002;30:2438–2442. doi: 10.1097/00003246-200211000-00006.

Hart DW, et al. Persistence of muscle catabolism after severe burn. Surgery. 2000;128:312–319. doi: 10.1067/msy.2000.108059.

KUMAR, A. (2019). The Scenario of Pharmaceuticals and Development of Microwave Assisted Extraction Techniques.

Patsouris D, et al. Burn induces browning of the subcutaneous white adipose tissue in mice and humans. Cell Rep. 2015;13:1538–1544. doi: 10.1016/j.celrep.2015.10.028.

Finnerty CC, et al. Determination of burn patient outcome by large-scale quantitative discovery proteomics. Crit. Care Med. 2013;41:1421–1434. doi: 10.1097/CCM.0b013e31827c072e.

Seok J, et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc. Natl Acad. Sci. USA. 2013;110:3507–3512. doi: 10.1073/pnas.1222878110.

Kumar, R., & Saha, P. (2022). A review on artificial intelligence and machine learning to improve cancer management and drug discovery. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 149-156.

Singer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) JAMA. 2016;315:801–810. doi: 10.1001/jama.2016.0287.

Kupper TS, Green DR, Durum SK, Baker CC. Defective antigen presentation to a cloned T helper cell by macrophages from burned mice can be restored with interleukin-1. Surgery. 1985;98:199–206.

Miyazaki H, Kinoshita M, Ono S, Seki S, Saitoh D. Burn-evoked reactive oxygen species immediately after injury are crucial to restore the neutrophil function against postburn infection in mice. Shock. 2015;44:252–257. doi: 10.1097/SHK.0000000000000404.

SHAFQAT ZAIDI, R. K., MEHRA, D., & ROSHAN, K. A. D. (2021). Effect of Kalahari Cactus Extract on Appetitte, Body Weight And Lipid Profile In Cafeteria Diet Induced Obesity In Experimental Animal. Annals of the Romanian Society for Cell Biology, 25(6), 13976-13987.

Hampson P, et al. Neutrophil dysfunction, immature granulocytes, and cell-free DNA are early biomarkers of sepsis in burn-injured patients: a prospective observational cohort study. Ann. Surg. 2017;265:1241–1249. doi: 10.1097/SLA.0000000000001807.

Antonacci AC, et al. Autologous and allogeneic mixed-lymphocyte responses following thermal injury in man: the immunomodulatory effects of interleukin 1, interleukin 2, and a prostaglandin inhibitor, WY-18251. Clin. Immunol. Immunopathol. 1984;30:304–320. doi: 10.1016/0090-1229(84)90064-3.

Saha, P., Kumar, A., Bhanja, J., Shaik, R., Kawale, A. L., & Kumar, R. (2022). A Review of Immune Blockade Safety and Antitumor Activity of Dostarlimab Therapy in Endometrial Cancer. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 201-209.

Jones CD, Ho W, Gunn E, Widdowson D, Bahia H. E-cigarette burn injuries: Comprehensive review and management guidelines proposal. Burns. 2019 Jun;45(4):763-771.

Gentges J, Schieche C, Nusbaum J, Gupta N. Points & Pearls: Electrical injuries in the emergency department: an evidence-based review. Emerg Med Pract. 2018 Nov 01;20(Suppl 11):1-2.

Gentges J, Schieche C. Electrical injuries in the emergency department: an evidence-based review. Emerg Med Pract. 2018 Nov;20(11):1-20.

Bugga, P., Alam, M. J., Kumar, R., Pal, S., Chattopadyay, N., & Banerjee, S. K. (2022). Sirt3 ameliorates mitochondrial dysfunction and oxidative stress through regulating mitochondrial biogenesis and dynamics in cardiomyoblast. Cellular Signalling, 94, 110309.

Huang HH, Lee YC, Chen CY. Effects of burns on gut motor and mucosa functions. Neuropeptides. 2018 Dec;72:47-57.

Dado DN, Huang B, Foster DV, Nielsen JS, Gurney JM, Morrow BD, Sharma K, Chung KK, Ainsworth CR. Management of calciphylaxis in a burn center: A case series and review of the literature. Burns. 2019 Feb;45(1):241-246.

Singh, Y., Paswan, S. K., Kumar, R., Otia, M. K., Acharya, S., Kumar, D., & Keshamma, E. (2022). Plant & Its Derivative Shows Therapeutic Activity on Neuroprotective Effect. Journal for Research in Applied Sciences and Biotechnology, 1(2), 10-24.

Badulak JH, Schurr M, Sauaia A, Ivashchenko A, Peltz E. Defining the criteria for intubation of the patient with thermal burns. Burns. 2018 May;44(3):531-538.

Clark A, Neyra JA, Madni T, Imran J, Phelan H, Arnoldo B, Wolf SE. Acute kidney injury after burn. Burns. 2017 Aug;43(5):898-908.

Kumar, R., Keshamma, E., Paswan, S. K., Saha, P., Trivedi, U., Chourasia, A., & Otia, M. (2022). Alkaloid Based Chemical Constituents of Ocimum santum & Cinchona Bark: A Meta Analysis. Journal for Research in Applied Sciences and Biotechnology, 1(2), 35-42.

Struck HG. [Chemical and Thermal Eye Burns]. Klin Monbl Augenheilkd. 2016 Nov;233(11):1244-1253.

Ottomann C, Hartmann B, Antonic V. Burn Care on Cruise Ships-Epidemiology, international regulations, risk situation, disaster management and qualification of the ship's doctor. Burns. 2016 Sep;42(6):1304-10.

Nyarko, R. O., Roopini, R., Raviteja, V., Awuchi, C. G., Kumar, R., Faller, E. M., ... & Saha, P. (2022). Novel Sars-CoV-2 Variants & Therapeutic Effects. Journal for Research in Applied Sciences and Biotechnology, 1(2), 25-34.

Vivó C, Galeiras R, del Caz MD. Initial evaluation and management of the critical burn patient. Med Intensiva. 2016 Jan-Feb;40(1):49-59

Amle, V. S., Rathod, D. A., Keshamma, E., Kumar, V., Kumar, R., & Saha, P. (2022). Bioactive Herbal Medicine Use for Eye Sight: A Meta Analysis. Journal for Research in Applied Sciences and Biotechnology, 1(3), 42-50.

Pandey, M., Singh, A., Agnihotri, N., Kumar, R., Saha, P., Pandey, R. P., & Kumar, A. (2022). Clinical Pharmacology & Therapeutic uses of Diuretic Agents: A Review. Journal for Research in Applied Sciences and Biotechnology, 1(3), 11-20.

Zuo KJ, Medina A, Tredget EE. Important Developments in Burn Care. Plast Reconstr Surg. 2017 Jan;139(1):120e-138e.

Vivó C, Galeiras R, del Caz MD. Initial evaluation and management of the critical burn patient. Med Intensiva. 2016 Jan-Feb;40(1):49-59.

Ramachandra T, Ries WR. Management of Nasal and Perinasal Soft Tissue Injuries. Facial Plast Surg. 2015 Jun;31(3):194-200.

Wu C, Calvert CT, Cairns BA, Hultman CS. Lower extremity nerve decompression in burn patients. Ann Plast Surg. 2013 May;70(5):563-7.

Toussaint J, Singer AJ. The evaluation and management of thermal injuries: 2014 update. Clin Exp Emerg Med. 2014 Sep;1(1):8-18.

Fish R, Davidson RS. Management of ocular thermal and chemical injuries, including amniotic membrane therapy. Curr Opin Ophthalmol. 2010 Jul;21(4):317-21.

Bayat A, Ramaiah R, Bhananker SM. Analgesia and sedation for children undergoing burn wound care. Expert Rev Neurother. 2010 Nov;10(11):1747-59.

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Published

2022-10-31

How to Cite

Kumar, R., Keshamma E, Kumari, B., Kumar, A., Kumar, V., Janjua, D., & Billah, A. M. (2022). Burn Injury Management, Pathophysiology and Its Future Prospectives. Journal for Research in Applied Sciences and Biotechnology, 1(4), 78–89. https://doi.org/10.55544/jrasb.1.4.10

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