Pharmacological Screening Model and Its Treatment of Peptic Ulcer Disease

Raghuvendra Singh; Anubha Gupta; Shweta Patel

doi:10.55544/jrasb.1.5.4

Authors

Raghuvendra Singh Associate Professor, Department of Pharmaceutical Chemistry, Advance Institute of Biotech and Paramedical Sciences, Kanpur Uttar Pradesh, INDIA.
Anubha Gupta Assistant Professor, Department of Pharmacy, Maharana Pratap College of Pharmaceutical Sciences, Kanpur Uttar Pradesh, INDIA.
Shweta Patel Assistant Professor, Department of Pharmacy, Maharana Pratap College of Pharmaceutical Sciences, Kanpur Uttar Pradesh, INDIA.

DOI:

https://doi.org/10.55544/jrasb.1.5.4

Keywords:

Helicobacter Pylori, PPI, Chronic disease, H2 Receptor Antagonist

Abstract

Peptic ulcer is a ceaseless sickness influencing up to 10% of the total population. Peptic ulcer created by the unevenness of gastric juice pH and mucosal protections. Two fundamental components delivered Peptic ulcer. Frist is central point it included bacterial disease, for example, Helicobacter Pylori (H. Pylori) and medicine non-steroidal anti-inflammatory medication and synthetic E.g., HCL, Ethanol. Second is minor factor it included pressure, smoking, fiery food and nourishment lopsidedness. Ordinary treatment of Peptic ulcer, for example, proton siphon inhibitor (PPI) and Histamine-2 (H2) Receptor Antagonist. Also, other Hand therapeutic plant and their concoction compound are valuable in the counteraction and treatment of peptic ulcer infection. Various creature models are utilizing to influenced ulcer to identifying the antiulcer activity of many new existed drugs such as Pylorus ligated (shay) rats, Stress ulcers, Restraint ulcer in rats, Water immersion-induced restraint ulcers, Cold and restraint ulcers, Gastric mucosal damage induced by NSAID in rats, Induced solitary chronic gastric ulcer, Acetic acid induced kissing gastric ulcers in rats Histamine induced gastric ulcer in guinea pig, Duodenal anti-ulcer activity, Gastric cytoprotective action.

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Dubey A, Ghosh NS, Singh R. Zebrafish as An Emerging Model: An Important Testing Platform for Biomedical Science. J Pharm Negative Results 2022;13(3):1-7. DOI:10.47750/pnr.2022.13.03.001.

Anubhav Dubey, Raghuvendra Singh, Ashish Kumar, Gaurav Mishra, Anubha Gupta, Anuj Sonker, & Amit Mishra. (2022). A Critical Review on Changing Epidemiology of Human Monkeypox-A Current Threat with Multi-Country Outbreak. Journal of Pharmaceutical Negative Results, 660–671. Retrieved from https://www.pnrjournal.com/index.php/home/article/view/738.

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Anubhav Dubey, Deepanshi Tiwari, Kshama Srivastava, Om Prakash and Rohit Kushwaha. A discussion on vinca plant. J Pharmacogn Phytochem 2020;9(5):27-31.