Review on Medicinal Herbs in the Treatment of Gout

Munna Kumar; Arti Kori; Shivanand M. Patil

doi:10.55544/jrasb.3.6.5

Authors

Munna Kumar Research Scholar, Department of Pharmacy, Shree Dev Bhoomi Institute of Education Science and Technology (SDBIT), Dehradun, INDIA.
Ms. Arti Kori Associate Professor, Department of Pharmacy, Shree Dev Bhoomi Institute of Education Science and Technology (SDBIT), Dehradun, INDIA.
Shivanand M. Patil Professor, Department of Pharmacy, Shree Dev Bhoomi Institute of Education Science and Technology (SDBIT), Dehradun, INDIA.

DOI:

https://doi.org/10.55544/jrasb.3.6.5

Keywords:

inflammation, hyperuricemia, allopurinol, monosodium urate crystal, xanthine oxidase inhibitor

Abstract

Joint urate crystals are the hallmark of the inflammatory condition known as gout. Acute gout is characterised by the abrupt development of swelling and pain that begins in the greater toe. This condition is linked to high levels of uric acid in the blood, which can occur when the kidneys do not excrete enough of the acid or when the body produces too much uric acid. Allopurinol, which inhibits the enzyme xanthine oxidase and hence lowers blood uric acid levels, is the mainstay of conventional gout treatment in contemporary medicine. Pain and inflammation can be managed with the help of nonsteroidal anti-inflammatory drugs (NSAIDs). It has also been seen that non-pharmacological approaches, such as dietary improvements, can improve patients' situations. Many people believe that herbal treatments are safer and more effective than conventional pharmaceuticals, especially when it comes to patient adherence and the potential for adverse effects. Celery and parsley, when used together, have demonstrated effects comparable to those of allopurinol. This article's goal is to provide a summary of allopurinol's herbal substitutes.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Monu Johnny U.V., Pope Thomas L, Gout: a clinical and radiology review, Radiologic Clinics of North America 2004, Page No- 169-184.

Khanna Puja P, Gladue Heather S, Singh Manjit K, Fitzgerald Jond D, Bae Sangmee, Prakash Shraddha, Kaldas Marian, Gogia Maneesh, Berrocal Veronica, Townsend Whitney, Terkeltaub Robert, Khanna Dinesh,Treatment of acute gout: A systematic review, Seminars in Arthritis and Rheumatism 2014 Page No- 31-38.

Brook Richard A, Forsythe Anna, Smeeding James E, Lawrence Edwards N, Chronic gout: epidemiology, disease progression, treatment and disease burden, Current Medical Research and Opinion, 2010 Page No- 2813-2821.

Perez-Ruiz Fernando, Dalbeth Nicola, Bardin Tomas, A Review of Uric Acid, Crystal Deposition Disease, and Gout, Advances in Therapy 2015 Page No- 31-41.

Eggebeen, Aaron T, Gout: An Update, American Family physician 2007 Page No-801-808.

Kumar, R., Saha, P., Kumar, Y., Sahana, S., Dubey, A., & Prakash, O. (2020). A review on diabetes mellitus: type1 & Type2. World Journal of Pharmacy and Pharmaceutical Sciences, 9(10), 838-850.

Saha, P., Kumar, A., Bhanja, J., Shaik, R., Kawale, A. L., & Kumar, R. (2022). A review of immune blockade safety and antitumor activity of dostarlimab therapy in endometrial cancer. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 201-209.

Nyarko, R. O., Roopini, R., Raviteja, V., Awuchi, C. G., Kumar, R., Faller, E. M., ... & Saha, P. (2022). Novel Sars-CoV-2 Variants & Therapeutic Effects. Journal for Research in Applied Sciences and Biotechnology, 1(2), 25-34.

Awuchi, C. G., Saha, P., Amle, V. S., Nyarko, R. O., Kumar, R., Boateng, E. A., ... & Asum, C. (2023). A Study of various medicinal plants used in ulcer treatment: A review. Journal for Research in Applied Sciences and Biotechnology, 2(1), 234-246.

Sultana, A., Singh, M., Kumar, A., Kumar, R., Saha, P., Kumar, R. S., & Kumar, D. (2022). To identify drug- drug interaction in cardiac patients in tertiary care hospitals. Journal for Research in Applied Sciences and Biotechnology, 1(3), 146-152.

Kumar, S., Keshamma, E., Trivedi, U., Janjua, D., Shaw, P., Kumar, R., ... & Saha, P. (2022). A meta analysis of different herbs (leaves, roots, stems) used in treatment of cancer cells. Journal for Research in Applied Sciences and Biotechnology, 1(3), 92-101.

Kumar, R., Keshamma, E., Kumari, B., Kumar, A., Kumar, V., Janjua, D., & Billah, A. M. (2022). Burn injury management, pathophysiology and its future prospectives. Journal for Research in Applied Sciences and Biotechnology, 1(4), 78-89.

Kumar, A., Katiyar, A., Gautam, V., Singh, R., & Dubey, A. (2022). A comprehensive review on anti-cancer properties of Amaranthus viridis. Journal for Research in Applied Sciences and Biotechnology, 1(3), 178-185.

Kumar, R., Jangir, D. K., Verma, G., Shekhar, S., Hanpude, P., Kumar, S., ... & Kanti Maiti, T. (2017). S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation. Scientific reports, 7(1), 44558.

Kumar, R., Register, K., Christopher-Hennings, J., Moroni, P., Gioia, G., Garcia-Fernandez, N., ... & Scaria, J. (2020). Population genomic analysis of Mycoplasma bovis elucidates geographical variations and genes associated with host-types. Microorganisms, 8(10), 1561.

Kumar, S., Yadav, S. P., Chandra, G., Sahu, D. S., Kumar, R., Maurya, P. S., ... & Ranjan, K. (2019). Effect of dietary supplementation of yeast (Saccharomyces cerevisiae) on performance and hemato-biochemical status of broilers.

Hanna, D., Kumar, R., & Banerjee, R. (2023). A metabolic paradigm for hydrogen sulfide signaling via electron transport chain plasticity. Antioxidants & Redox Signaling, 38(1-3), 57-67.

Keshri, S., Kumar, R., Kumar, D., Singhal, T., Giri, S., Sharma, I., & Vatsha, P. (2022). Insights Of Artificial Intelligence In Brain Disorder With Evidence Of Opportunity And Future Challenges. Journal of Pharmaceutical Negative Results, 10853-10867.

Kumar, A., Uniyal, Y., & Kumar, R. (2022). Recent Advancement of Colorectal Cancer and Their Herbal Essential Oil Treatment. Journal for Research in Applied Sciences and Biotechnology, 1(5), 133-144.

Chaudhary, H., Sagar, S., Kumar, R., Bisht, V., & Butola, K. (2022). Herbal Essential Oil use as Ulcer Protective Activity: A Systematic Review. Journal for Research in Applied Sciences and Biotechnology, 1(5), 86-101.

Kashyap, N., Kumar, R., Rana, V., Sood, P., & Chauhan, T. (2023). Role of Terpenoids Active Ingredients Targeting for Neuroprotective Agents. Journal for Research in Applied Sciences and Biotechnology, 2(3), 22- 40.

Raj, R., Kumar, A., Sood, P., Kumar, R., & Rana, V. (2023). Randomized Phase III Trial Comparing Epirubicin/Doxorubicin Plus Docetaxel and Epirubicin/Doxorubicin Plus Paclitaxel as First Line Treatment in Women with Advanced Breast Cancer. Journal for Research in Applied Sciences and Biotechnology, 2(3), 55- 63.

Kumar, R. (2023). Investigation of In-Vitro Method of Antiulcer Activity. Journal for Research in Applied Sciences and Biotechnology, 2(1), 264-267.

Borghi Claudio, The management of hyperuricemia: back to the pathophysiology of uric acid, Current Medical Research and Opinion 2017, Page No- 1-4.

Kanwal Ashiq, Abida Latif, Sana Ashiq , Ahlam Sundus, A systematic review on the prevalence, pathophysiology, diagnosis, management and treatment of gout (2007-2018), GSC Biological and Pharmaceutical Sciences, 2018, Page No- 50- 55. Khan

Akram Muhammad, Usmanghani Khan, Ahmed Iqbal, Azhar Iqbal, and Hamid Abdul, Comprehensive review on therapeutic strategies of gouty arthritis, Corresponding author 2014, Page No- 1575-1582.

Robinson Philip C and Dalbeth Nicola, Advances in pharmacotherapy for the treatment of gout, Expert Opinion on Pharmacotherapy 2014 Page- 1-4.

Roddy E and Doherty M, Epidemiology of Gout, Arthritis Research and Therapy 2010,12:223

Aung Thanda, Myung Gihyun, and FitzGerald John D, Treatment approaches and adherence to uratelowering therapy for patients with gout, Patient Preference and Adherence 2017, Page No- 795-800.

Kapoor Bhupinder, Kaur Gagandeep, Gupta Mukta, Gupta Reena, Indian Medicinal Plants In Treatment of Gout: A Review For Current Status and Future Prospective, Asian Journal of Pharmaceutical and Clinical Research 2017, Page No- 1-10.

Ashiq Kanwal, Hussain Khalid, Islam Muhammad, Shehzadi Naureen, Ali Ejaz, Ashiq Sana, Medicinal plants of Pakistan and their xanthine oxidase inhibition activity to treat gout: a systematic review, Turkish Journal of Botany, 2021,Page No- 1-18.

Abd El-Rahman Hanna S.M. and Abd- El Hak Nasra A.M., Xanthine Oxidase Inhibitory Activity and Antigout of Celery Leek Parsley and Molokhia, Advances in Biochemistry 2015, Page No- 1-11.

Soliman Mohamed, Nassan Abdo Mohamed, Aldhahrani1 Adil, Althobaiti Fayez and Mohamed Abdou Wafaa, Molecular and Histopathological Study on the Ameliorative Impacts of Petroselinum Crispum and Apium Graveolens against Experimental Hyperuricemia, Nature research 2020, page no-1-11.

Karim Abdul, Ali Bhatti Shabir M., Johnson Noman, Akhter Mahreen, Mona Sundus and Safder Zartasha, Effect of Apium Graveolens (Celery) Seed Extract on Serum Uric Acid Level of Hyperuricemic Rats and its Comparison with Allopurinol, Journal of Shalamar Medical and Dental College, 2021 Page No- 1-7.

Bibi Hafsa, Shahid Tahreem and Ain Quratul, Search for the Natural Remedies for the Treatment of Gout, Phytopharmacological Communications 2022 Page No- 193-204.

Singh Akshay K, Srivastava Anjali, Kumar Vivek and Singh Karunakar, Phytochemicals, Medicinal and Food Applications of Shatavari (Asparagus racemosus): An Updated Review, The Natural Products Journal, 2018, Page No- 32-44.

Bryan T and Emmerson, The Management of Gout ,Drug Therapy ,CORE 1996, Page No- 445-449.

Eggebeen , Aaron T, Gout: An Update , American Family physician 2007 Page No-801-808.

So Alexander , Developments in the Scientific and Clinical understanding of Gout , Arthritis Research and Therapy 2008, 10:221

Martinon Fabio and Glimcher Laurie H, Gout: new insights into an old disease, The Journal of Clinical Investigation 2006 , Page No- 2073-2075.

So Alexander and Busso Nathalie, Mechanisms of inflammation in Gout, Arthritis Research and Therapy 2010, 12:206

Doherty Michael, Jansen Tim L, Nuki George, Pascual Eliseo, Perez-Ruiz Fernando, Punzi Leonardo, So Alexander k, Bardin Thomas, Gout: Why is this Curable disease So Seldom Cured? Annrheumdis 2012 Page No- 1-6.

Cronstein Bruce N and Terkeltaub Robert, The inflammatory Process of gout and its treatment, Arthritis Research and Therapy 2006 Page No- 1-7.

Major Tanya J, Dalbeth Nicola, Stahl Eli A and Merriman Tony R, An update on the genetics of hyperuricaemia and Gout, Nature Reviews Rheumatology 2018, Page No- 1-13.

Monu Johnny U.V. ,Pope Thomas L, Gout: a clinical and radiology review, Radiologic Clinics of North America 2004 , Page No- 169-184.

Saag Kenneth G and Choi Hyon, Epidemiology, risk factors, and Lifestyle modifications for gout , Arthritis Research and therapy 2006 Page No- 1-7.

Malik A, Schumacher HR, Dinnella JE, Clayburne GM: Clinical diagnostic criteria for gout: comparison with the gold standard of synovial fl uid crystal analysis. J Clin Rheumatol 2009, 15:22- 24

Roddy E: Hyperuricemia, gout, and lifestyle factors. J Rheumatol 2008, 35:1689-1691.

Emmerson BT. The management of gout. N Engl J Med 1996;334 Page No- 445 – 451.

Heber D. PDR for Herbal Medicines, 4th ed. Thomson Healthcare Inc.; 2007. 1026 p.

Maiuolo, J., Oppedisano, F., Gratteri, S., Muscoli, C. & Mollace, V. Regulation of uric acid metabolism and excretion. Int. J. Cardiol. 213,Page No- 8–14.

Dolati, K. et al. Inhibitory Effects of Apium graveolens on Xanthine Oxidase Activity and Serum Uric Acid Levels in Hyperuricemic Mice. Preventive Nutr. food Sci. 23,Page No- 127–133.

Harris, Siegel LB, Alloway JA. Gout and hyperuricemia. Am Fam Physician 1999 Page No- 925 – 934.

Terkeltaub R: Pathogenesis and treatment of crystal-induced inflammation. In Arthritis and Allied Conditions, 15th ed. Edited by Koopman WJ, Moreland LW. Philadelphia: Lippincott, Williams and Wilkins; 2004 Page No- 2357-2372.

Terkeltaub RA: Clinical practice. Gout. N Engl J Med 2003, 349: 1647-1655.

Choi HK, Mount DB, Reginato AM: Pathogenesis of gout. Ann Intern Med 2005, 143:499-516.

Choi, H.K., Atkinson, K., Karlson, E.W., Willett, W. & Curhan, G. Purine- rich foods, dairy and protein intake, and the risk of gout in men. N Engl J Med 350, 1093-103 (2004).

Merriman, T.R. An update on the genetic architecture of hyperuricemia and gout. Arthritis Res Ther 17, 98 (2015).

Dalbeth N, Haskard DO. Mechanisms of inflammation in gout. Rheumatology (Oxford) 2005;44:Page No- 1090–6.

Simkin PA. Gout and hyperuricemia. Curr Opin Rheumatol 1997;9(3): Page N - 268 – 273

Asplin JR. Uric acid stones. Semin Nephrol 1996; 16(5): Page No- 412-424