In-vitro Anti-Ulcer Activities of Mallotus Japonicus

Sweta S Koka; Devshree Gayakwad; Shraddha; Sonali Santosh Kadam; Ritesh Jha; Anil Kumar; Mihir Kedarbhai Otia

doi:10.55544/jrasb.1.5.2

Authors

Dr. Sweta S Koka Associate Professor, Acropolis Institute of Pharmaceutical Education and Research Indore, 453771, INDIA.
Devshree Gayakwad Assistant Professor, Acropolis Institute of Pharmaceutical Education and Research, Indore 452001, INDIA.
Shraddha Mahajan Assistant Professor, Acropolis Institute of Pharmaceutical Education and Research Indore 453771, INDIA.
Dr. Sonali Santosh Kadam Associate Professor in Botany, R. P. Gogate and R. V. Jogalekar College Ratnagiri Maharashtra, INDIA.
Ritesh Jha Department of Pharmacy, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun-248007, Uttarakhand, INDIA.
Dr. Anil Kumar Department of Botany, DDU Gorakhpur University, Gorakhpur-273009, INDIA.
Mihir Kedarbhai Otia Pharmaceutical Technology, Babaria Institute of Pharmacy Vadodara, Gujarat Technological University, Gujarat, INDIA.

DOI:

https://doi.org/10.55544/jrasb.1.5.2

Keywords:

In-vitro, Proton pump Inhibitor, Gastric Mucosal, Herbal plants

Abstract

Objectives: This study's objective was to investigate whether or not a methanolic extract of Mallotus japonicas could decrease H+-K+ ATPase activity and neutralise acid.

Materials and Methods: We assessed the total phenolic and flavonoid contents of the sample while it was exposed to varying amounts of standard esmoprazole and methanol extract.

Results: The proton pump inhibitory activity of the extract from stomach mucosal homogenate was found to be significant (*P<0.05) and on par with the standard.

Conclusions: Based on these findings, it may be concluded that the proton pump can be effectively blocked by the methanolic extract.

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References

Chiarelli-Neto O, Ferreira AS, Waleska KM, Pavani C, Severino D, Faião-Flores F, et al. Melanin photosensitization and the effect of visible light on epithelial cells. PLoS One 2014; 9(11): e113266.

Awuchi, C. G., Amagwula, I. O., Priya, P., Kumar, R., Yezdani, U., & Khan, M. G. (2020). Aflatoxins in foods and feeds: A review on health implications, detection, and control. Bull. Environ. Pharmacol. Life Sci, 9, 149-155.

Ogura R, Sugiyama M, Nishi J, Haramaki M. Mechanism of lipid radical formation following exposure of epidermal homogenate to ultraviolet light. J Invest Dermatol 1991; 97(6): 1044-7.

Kumar, R., Saha, P., Lokare, P., Datta, K., Selvakumar, P., & Chourasia, A. (2022). A Systemic Review of Ocimum sanctum (Tulsi): Morphological Characteristics, Phytoconstituents and Therapeutic Applications. International Journal for Research in Applied Sciences and Biotechnology, 9(2), 221-226.

Taira J, Mimura K, Yoneya T, Hagi A, Murakami A, Makino K. Hydroxyl radical formation by UV-irradiated epidermal cells. J Biochem 1992; 111(6): 693-5.

Bind, A., Das, S., Singh, V. D., Kumar, R., Chourasia, A., & Saha, P. Natural Bioactives For The Potential Management Of Gastric Ulceration. Turkish Journal of Physiotherapy and Rehabilitation, 32(3).

Chang TS. An updated review of tyrosinase inhibitors. Int J Mol Sci 2009; 10: 2440-75.

Singh, M. K., Kumar, A., Kumar, R., Kumar, P. S., Selvakumar, P., & Chourasia, A. (2022). Effects of Repeated Deep Frying on Refractive Index and Peroxide Value of Selected Vegetable Oils. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 28-31.

Franco DC, de Carvalho GS, Rocha PR, da Silva Teixeira R, da Silva AD, Raposo NR. Inhibitory effects of resveratrol analogs on mushroom tyrosinase activity. Molecules 2012; 17: 11816-25.

Dubey, A., Yadav, P., Verma, P., & Kumar, R. (2022). Investigation of Proapoptotic Potential of Ipomoea carnea Leaf Extract on Breast Cancer Cell Line. Journal of Drug Delivery and Therapeutics, 12(1), 51-55.

Souza PM, Elias ST, Simeoni LA, de Paula JE, Gomes SM, Guerra EN, et al. Plants from Brazilian cerrado with potent tyrosinase inhibitory activity. PLoS One 2012; 7(11): e48589.

Daharia, A., Jaiswal, V. K., Royal, K. P., Sharma, H., Joginath, A. K., Kumar, R., & Saha, P. (2022). A Comparative review on ginger and garlic with their pharmacological Action. Asian Journal of Pharmaceutical Research and Development, 10(3), 65-69.

Kumar, R., & Saha, P. (2022). A review on artificial intelligence and machine learning to improve cancer management and drug discovery. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 149-156.

Kim SS, Kim MJ, Choi YH, Kim BK, Kim KS, Park KJ, et al. Down-regulation of tyrosinase, TRP-1, TRP-2 and MITF expressions by citrus press-cakes in murine B16 F10 melanoma. Asian Pac J Trop Biomed 2013; 3(8): 617-22.

Saha, P., Kumar, R., Nyarko, R. O., Kahwa, I., & Owusu, P. (2021). herbal secondary metabolite for gastro-protective ulcer activity with api structures.

Nyarko, R. O., Kumar, R., Sharma, S., Chourasia, A., Roy, A., & Saha, P. (2022). antibacterial activity of herbal plant-tinospora cordifolia and catharnthus roseus.

Tabata H, Katsube T, Moriya K, Utsumi T, Yamasaki Y. Protective activity of components of an edible plant, Mallotus japonicus, against oxidative modification of proteins and lipids. Food Chem 2010; 118: 548-53.

Kumar, R., & Saha, P. (2022). A review on artificial intelligence and machine learning to improve cancer management and drug discovery. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 149-156.

Singh, Y., Paswan, S. K., Kumar, R., Otia, M. K., Acharya, S., Kumar, D., & Keshamma, E. (2022). Plant & Its Derivative Shows Therapeutic Activity on Neuroprotective Effect. Journal for Research in Applied Sciences and Biotechnology, 1(2), 10-24.

Kim HS, Lim HK, Chung MW, Kim YC. Antihepatotoxic activity of bergenin, the major constituent of Mallotus japonicus, on carbon tetrachloride-intoxicated hepatocytes. J Ethnopharmacol 2000; 69: 79-83.

Saha, P., Kumar, A., Bhanja, J., Shaik, R., Kawale, A. L., & Kumar, R. (2022). A Review of Immune Blockade Safety and Antitumor Activity of Dostarlimab Therapy in Endometrial Cancer. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 201-209.

Ishii R, Horie M, Saito K, Arisawa M, Kitanaka S. Inhibition of lipopolysaccharide-induced pro-inflammatory cytokine expression via suppression of nuclear factor-kB activation by Mallotus japonicus phloroglucinol derivatives. Biochim Biophys Acta 2003; 1620: 108-18.

Kumar, R., Keshamma, E., Paswan, S. K., Saha, P., Trivedi, U., Chourasia, A., & Otia, M. (2022). Alkaloid Based Chemical Constituents of Ocimum santum & Cinchona Bark: A Meta Analysis. Journal for Research in Applied Sciences and Biotechnology, 1(2), 35-42.

Anubhav, S. P. D., Sanjay, K. D., & Roshan, K. (2022). Evaluation of Enzyme Producing K. Pneumoniae and Their Susceptibility to Other Anti-Biotics. International Journal of Innovative Science and Research Technology, 7(5), 351-353.

Taira J, Nanbu H, Ueda K. Nitric oxide-scavenging compounds in Agrimonia pilosa Ledeb on LPS-induced RAW264.7 macrophages. Food Chem 2009; 115: 1221-7.

Amle, V. S., Rathod, D. A., Keshamma, E., Kumar, V., Kumar, R., & Saha, P. (2022). Bioactive Herbal Medicine Use for Eye Sight: A Meta Analysis. Journal for Research in Applied Sciences and Biotechnology, 1(3), 42-50.

Pandey, M., Singh, A., Agnihotri, N., Kumar, R., Saha, P., Pandey, R. P., & Kumar, A. (2022). Clinical Pharmacology & Therapeutic uses of Diuretic Agents: A Review. Journal for Research in Applied Sciences and Biotechnology, 1(3), 11-20.

Taira J, Taira K, Ohmine W, Nagata J. Mineral determination and anti-LDL oxidation activity of sweet potato (Ipomoea batatas L.) leaves. J Food Compost Anal 2013; 29: 117-25.

Yadav, A. N., Verma, P., Kumar, R., Kumar, S., Kumar, V., Kumar, K., & Dhaliwal, H. S. (2017, October). Probiotic microbes: Biodiversity, mechanisms of action and potential role in human health. In Proceedings of the National Conference on Advances in Food Science and Technology, Paris, France (pp. 23-25).

Ito S, Ojika M, Yamashita T, Wakamatsu K. Tyrosinase-catalyzed oxidation of rhododendrol produces 2-methylchromane-6,7-dione, the putative ultimate toxic metabolite: implications for melanocyte toxicity. Pigment Cell Melanoma Res 2014; 27: 744-53.

Kumar, S., Yadav, S. P., Chandra, G., Sahu, D. S., Kumar, R., Maurya, P. S., ... & Ranjan, K. (2019). Effect of dietary supplementation of yeast (Saccharomyces cerevisiae) on performance and hemato-biochemical status of broilers.

Tabata H, Katsube T, Tsuma T, Ohta Y, Imawaka N, Utsumi T. Isolation and evaluation of the radical-scavenging activity of the antioxidants in the leaves of an edible plant, Mallotus japonicus. Food Chem 2008; 109: 64-71.

Nyarko, R. O., Kumar, R., Sharma, S., & Chourasia, A. (2022). Ayushmann Roy, and Purabi Saha.". Antibacterial Activity Of Herbal Plant-Tinospora Cordifolia And Catharnthus Roseus.

Nyarko, R. O., Awuchi, C. G., Kumar, R., Boateng, E., Kahwa, I., Boateng, P. O., ... & Saha, P. (2022). Evaluation of Cafeteria Diet in Experimental Animal with Plant Extract of Calotropis procera for Obesity Parameter. Journal for Research in Applied Sciences and Biotechnology, 1(3), 107-113.

Arung ET, Furuta S, Ishikawa H, Kusuma IW, Shimizu K, Kondo R. Anti-melanogenesis properties of quercetin- and its derivative-rich extract from Allium cepa. Food Chem 2011; 124: 1024-8.

Saha, P. (2020). EVOLUTION OF TOLBUTAMIDE IN THE TREATMENT OF DIABETES MELLITUS. Diabetes, 2, 10.

Kumar, S., Keshamma, E., Trivedi, U., Janjua, D., Shaw, P., Kumar, R., ... & Saha, P. (2022). A Meta Analysis of Different Herbs (Leaves, Roots, Stems) Used in Treatment of Cancer Cells. Journal for Research in Applied Sciences and Biotechnology, 1(3), 92-101.

Chen XX, Shi Y, Chai WM, Feng HL, Zhuang JX, Chen QX. Condensed tannins from Ficus virens as tyrosinase inhibitors: structure, inhibitory activity and molecular mechanism. PLoS One 2014; 9(3): e91809.

Pandey, M., Singh, A., Namrata, N. A., Kumar, R., Saha, P., Pandey, R. P., & Kumar, A. Shiwangi.(2022). Clinical Pharmacology & Therapeutic uses of Diuretic Agents: A Review. Journal for Research in Applied Sciences and Biotechnology, 1(3), 11-20.

Keshamma, E., Kumar, A., Jha, R., Amle, V. S., Dudhate, G. S., Patel, D., ... & Kumar, R. (2022). Breast Cancer Treatment Relying on Herbal Bioactive Components. Journal for Research in Applied Sciences and Biotechnology, 1(4), 105-115.

Kumar, R., Singh, A., & Painuly, N. (2022). INVESTIGATION OF IN-VITRO ANTI-OXIDANT & ANTI-ULCER ACTIVITY OF POLYHERBAL MEDICINAL PLANTS. Journal of Pharmaceutical Negative Results, 2077-2088.

Mishra, A., Singh, Y., Singh, R., Kumar, R., Shukla, S., Kumar, R., ... & Pol, S. L. (2022). Ethano-pharmacology activity & Antioxidant activity of Centella asiatica Plant Parts. NEUROQUANTOLOGY, 20(11), 7562-7572.

Singhal, A. K. V., Giri, S., & Kumar, R. (2022). INVESTIGATION OF IN-VITRO ANTI-OXIDANT & ANTI-ULCER ACTIVITY OF ANGIOGENESIS LATIFOLIA ROXB (DHAVA). NEUROQUANTOLOGY, 20(11), 5680-5686.

Mishra, A., Singh, Y., Singh, R., Kumar, R., Shukla, S., Kumar, R., ... & Pol, S. L. (2022). Ethano-pharmacology activity & Antioxidant activity of Centella asiatica Plant Parts. NEUROQUANTOLOGY, 20(11), 7562-7572.