Preclinical Evaluation of Tropic Activity on Isolated Frog Heart by Using Volatile Oil of Nigella sativa Seeds

Sanchita Subhendunath Samadder; Shristi Singh; Anumita Saha; Aishi Chatterjee; Mrityunjoy Majumdar; Sourav Roy; Prodip Roy

doi:10.55544/jrasb.1.4.1

Authors

Sanchita Subhendunath Samadder Student, Department of Pharmacology, Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdah, Nadia, West Bengal - 741222, INDIA.
Shristi Singh Student, Department of Pharmacology, Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdah, Nadia, West Bengal - 741222, INDIA.
Anumita Saha Student, Department of Pharmacology, Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdah, Nadia, West Bengal - 741222, INDIA.
Aishi Chatterjee Student, Department of Pharmacology, Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdah, Nadia, West Bengal - 741222, INDIA.
Dr. Mrityunjoy Majumdar Professor (H.O.D), Department of Pharmacology, Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdah, Nadia, West Bengal - 741222, INDIA.
Sourav Roy Assistant Professor, Department of Pharmacology, Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdah, Nadia, West Bengal - 741222, INDIA.
Prodip Roy Assistant Professor, Department of Pharmacology, Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdah, Nadia, West Bengal - 741222, INDIA.

DOI:

https://doi.org/10.55544/jrasb.1.4.1

Keywords:

cardiotropic, herbal remedies, bradycardia, cardiac arrest, hypotensive, volatile oil

Abstract

The lifestyle of people has changed over the time. Before the revolution days, people suffered from various diseases and the availability of medicines were not available. Today’s life is busier. Healthcare system has improved a lot but at the same time the number of people getting affected by different sources is still on a rise. The number one cause of death worldwide is due to heart diseases. The death rates due to cardiovascular disease increased. In order to improve the health conditions, there is a continuous development of synthetic and herbal medicines. Recently, rise in the use of herbal medicines have due to its natural origins and less side effects. One of the emerging herbs is Nigella sativa described as the remedy of all diseases. The tropic activity of the extracted volatile oil from Nigella sativa is observed on the isolated frog’s heart. The heart was isolated from the frog and was treated with adrenaline and acetylcholine to study its activity respectively. The isolated heart was also treated with the volatile oil of Nigella sativa seeds which produced dose dependent bradycardia like situation followed by cardiac arrest.

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References

Rastogi S, Pandey MM, Rawat AK. (2016). Traditional herbs: a remedy for cardiovascular disorders. Phytomedicine, 23(11), 1082-9. DOI: 10.1016/j.phymed.2015.10.012.

Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. (2013). A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed, 3(5), 337-52. DOI: 10.1016/S2221-1691(13)60075-1.

Meral, I (2004). et al. "Effect of Nigella sativa L. on heart rate and some haematological values of alloxan-induced diabetic rabbits." Scandinavian Journal of Laboratory Animal Sciences 31(1), 49-53.

Ugur AR, Dagi HT, Ozturk B, Tekin G, Findik D. (2016). Assessment of In vitro Antibacterial Activity and Cytotoxicity Effect of Nigella sativa Oil. Pharmacogn Mag.12(l4):S471-S474.DOI: 10.4103/0973-1296.191459.

Toma, C.-C.; Olah, N.-K.; Vlase, L.; Mogoșan, C.; Mocan, A. (2015). Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds. Molecules. 20, 9560-9574.DOI: org/10.3390/molecules20069560

Sahebkar, Amirhossein, et al. &quot (2016). A systematic review and meta-analysis of randomized controlled trials investigating the effects of supplementation with Nigella sativa (black seed) on blood

pressure.&quot, Journal of hypertension 34(11), 2127-2135.

K.M Fararh, Y Atoji, Y Shimizu, T Shiina, H Nikami, T Takewaki. (2004). Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic

hamsters,Research in Veterinary Science,Volume 77, Issue 2,Pages 123-129,ISSN 0034- 5288,DOI: org/10.1016/j.rvsc.2004.03.002.

Meral, I., et al. &quot. (2004). Effect of Nigella sativa L. on heart rate and some haematological values of alloxan-induced diabetic rabbits." Scandinavian Journal of Laboratory Animal Sciences 31(1), 49-53.

Kokoska L, Havlik J, Valterova I, Sovova H, Sajfrtova M, Jankovska I. (2008). Comparison of chemical composition and antibacterial activity of Nigella sativa seed

essential oils obtained by different extraction methods. Journal of food protection.71(12):2475-80.

KD Tripathi, (2019). Essential of Medical Pharmacology. (8th edition). Jaypee Brothers Medical Publishers (P) Ltd., New Delhi 110002, India.

Riishede, L., & Nielsen-Kudsk, F. (1990). Myocardial Effects of Adrenaline, Isoprenaline and Dobutamine at Hypothermic Conditions. Pharmacology & Toxicology, 66(5),354–360. DOI:10.1111/j.1600-0773.1990.tb00762.x

https://rjptonline.org/HTML_Papers/Research%20Journal%20of%20Pharmacy%20and%20Technology__PID__2019-12-8-33.html

Chan, D. K. O., & Chow, P. H. (1976). The effects of acetylcholine, biogenic amines and other vasoactive agents on the cardiovascular functions of the eel,Anguilla japonica. Journal of Experimental Zoology, 196(1), 13–26. DOI:10.1002/jez.1401960103

Iizuka H. Nihon Yakurigaku Zasshi. 1983, Cardiac effects of acetylcholine and its congeners. 81(5):441-9.

El Tahir, K. E. H., Ashour, M. M. S., & Al-Harbi, M. M. (1993). The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action. General Pharmacology: The Vascular System, 24(5), 1123–1131. DOI:10.1016/0306-3623(93)90359-6

Fallah Huseini, H., Amini, M., Mohtashami, R., Ghamarchehre, M. E., Sadeqhi, Z., Kianbakht, S., & Fallah Huseini, A. (2013). Blood Pressure Lowering Effect of Nigella sativaL. Seed Oil in Healthy Volunteers: A Randomized, Double-Blind, Placebo-controlled Clinical Trial. Phytotherapy Research, 27(12), 1849–1853. DOI:10.1002/ptr.4944

Dehkordi, F. R., & Kamkhah, A. F. (2008). Antihypertensive effect ofNigella sativaseed extract in patients with mild hypertension. Fundamental & Clinical Pharmacology, 22(4), 447–452. DOI:10.1111/j.1472-8206.2008.00607.x