Clinical Pharmacology & Therapeutic uses of Diuretic Agents: A Review

Authors

  • Mayankesh Pandey Principal, Vidya Bhavan College of Pharmacy, Rautapur, Chaubeypur, Kanpur Uttar Pradesh, INDIA.
  • Akanksha Singh Research Scholar, Department of Pharmacy, Advance Institute of Biotech and Paramedical Sciences, Kanpur, Uttar Pradesh, INDIA.
  • Namrata Research Scholar, Department of Pharmacy, Advance Institute of Biotech and Paramedical Sciences, Kanpur, Uttar Pradesh, INDIA.
  • Nidhee Agnihotri Assistant Professor, Department of Pharmaceutical Chemistry, Maharana Pratap College of Pharmaceutical Sciences, Kanpur Uttar, Pradesh, INDIA.
  • Roshan Kumar Research Scholar, Department of Pharmacology, Dev Bhoomi Institute of Pharmacy and Research, Dehradun, Uttarakhand, INDIA.
  • Purabi Saha Department of Pharmacy, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun-248007, Uttarakhand, INDIA.
  • Ravi Pratap Pandey Assistant Professor, Department of Pharmacology, Advance Institute of Biotech and Paramedical Sciences, Kanpur Uttar Pradesh, INDIA.
  • Amit Kumar Research Scholar, Department of Pharmacy, Advance Institute of Biotech and Paramedical Sciences, Kanpur, Uttar Pradesh, INDIA.
  • Shiwangi Research Scholar, Dept. of Pharmaceutics, Shri Ramnath Singh Institute of Pharmaceutical Science and Technology, Sitholi, Gwalior, INDIA.

DOI:

https://doi.org/10.55544/jrasb.1.3.3

Keywords:

Diuretics, inhibitor, Hypercalcemia, Heart failure, Pharmacokinetics dosing

Abstract

The osmolarity of both blood and urine will increase if the kidneys are unable to eliminate excess water and electrolytes. NPS can be treated by restricting salt intake and using diuretics. Loop diuretics. Salt and water are flushed out of the body by diuretics. Medications have a sodium-lowering effect. arteries parched with salt BP-lowering. Albumin and diuretics both have the effect of decreasing sensitivity. Furosemide inhibits albumin. Fail-safe. Albuminuria, coagulopathy, dyslipidemia, edema. Diuretics are used to treat both edema and non-edema. Diuretics are used to treat heart failure, high blood pressure, and ascites (and other disorders when applicable). Treatment of heart failure, side effects, off-label usage, dose, pharmacokinetics, monitoring, and interactions are all topics that will be covered in this article. Thiazide diuretics that are authorized by the FDA impede between 3 and 5 percent of nephron DCT sodium reabsorption. Thiazides cause a person to urinate more often. Nephron trafficking is slowed down when diuretics are used. Furosemide, bumetanide, torsemide inhibit Na-K-2Cl (SLC12A1). Chloride-binding proteins can only be bound to by anions. Perform the initial dose once again. Bronchodilators that open up the airways. The administrator of the test will be able to tell if your airways constrict (spirometry). Chemicals that because inflammation weaken smooth muscle. Drops of 15 percent in the forced expiratory volume in one second (FEV1) suggest airway hyperreactivity and inflammation.

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References

Dubey, A., Ghosh, N. S., Rathor, V. P. S., Patel, S., Patel, B., &Purohit, D. (2022).Sars- COV-2 infection leads to neurodegenerative or neuropsychiatric diseases. International Journal of Health Sciences, 6(S3), 2184–2197. https://doi.org/10.53730/ijhs.v6nS3.5980.

Saha, P., Nyarko, R. O., Lokare, P., Kahwa, I., Boateng, P. O., & Asum, C. (2022). Impact of Covid-19 in Management of Lung Cancer Disease: A Review. Asian Journal of Pharmaceutical Research and Development, 10(3), 58-64.

Anubhav Dubey, Yatendra Singh. Medicinal Properties of Cinchona Alkaloids - A Brief Review. Asian Journal of Research in Pharmaceutical Sciences. 2021; 11(3):224-8. doi: 10.52711/2231-5659.2021.00036

Yadav, K., Sachan, A., Kumar, S., & Dubey, A. (2022). Techniques For Increasing Solubility: A Review Of Conventional And New Strategies. Asian Journal of Pharmaceutical Research and Development, 10(2), 144-153.

Kumar, A. ., Dubey, A. ., & Singh, R. . (2022). Investigation on Anti-Ulcer Activity of Momordica dioica Fruits in Wistar Rat. International Journal for Research in Applied Sciences and Biotechnology, 9(1), 105–111. https://doi.org/10.31033/ijrasb.9.1.12

AnubhavDubey, Deepanshi Tiwari,Yatendra Singh, Om Prakash, PankajSingh. Drug repurposing in Oncology: Opportunities and challenges. Int J of Allied Med Sci and Clin Res 2021; 9(1): 68-87.

Dubey Anubhav, Tiwari Mamta, Kumar Vikas, Srivastava, Kshama, Singh, Akanksha. Investigation of Anti-Hyperlipidemic Activity of Vinpocetine in Wistar Rat international Journal of Pharmaceutical Research 2020; 12(02):1879-1882

Akshay Tiwari, Shalini Singh, Anubhav Dubey and Yatendra Singh. “A preliminary study on anti-hyperlipidemic activity of cinnamon oil in wistar rat”, 2021. International Journal of Current Research, 13, (03), 16741-16745.

Dubey Anubhav, Tiwari M, Singh Yatendra, Kumar N, Srivastava K. Investigation of anti-Pyretic activity of vinpocetine in wistar rat, International Journal of Pharmaceutical Research 2020;12(2):1901-1906.

Srivastava Kshama, Dubey Anubhav, Tiwari Mamta, Dubey Anurag, To evaluate the synergistic effect of pinitol with glimepride in diabetic wistar rats;7,(13)2020, 2058-2062.

Dubey A., Kumar R., Kumar S., Kumar N., Mishra A., Singh Y. and Tiwari M. (2020). Review on Vinpocetine, Int. J. of Pharm. & Life Sci., 11(5): 6590-6597.

Dubey, A., Yadav, P., Verma, P., & Kumar, R. (2022). Investigation of Proapoptotic Potential of Ipomoea carnea Leaf Extract on Breast Cancer Cell Line. Journal of Drug Delivery and Therapeutics, 12(1), 51-55.

Kumar N., Dubey A., Mishra A. And Tiwari P. (2020). Ethosomes: A Novel Approach in Transdermal Drug Delivery System, Int. J. of Pharm. & Life Sci., 11(5): 6598-6608.

Srivastava K., Tiwari M., Dubey A. and Dwivedi A. (2020). D-Pinitol - A Natural Phytomolecule and its Pharmacological effect, Int. J. of Pharm. & Life Sci., 11(5): 6609-6623.

Sahana, S., Kumar, R., Nag, S., Paul, R., Chatterjee, I., & Guha, N. (2020). A REVIEW ON ALZHEIMER DISEASE AND FUTURE PROSPECTS.

Kumar, R., & Dubey, A. PHYTOCHEMICAL INVESTICATION AND HEPTOPROTECTIVE EVALUTION ACACIA RUBICA EXTRACT ISONIZED AND PARACETAMOL INDUSED ANIMAL TOXICITY. Turkish Journal of Physiotherapy and Rehabilitation, 32(3).

Daharia, A., Jaiswal, V. K., Royal, K. P., Sharma, H., Joginath, A. K., Kumar, R., & Saha, P. (2022). A Comparative review on ginger and garlic with their pharmacological Action. Asian Journal of Pharmaceutical Research and Development, 10(3), 65-69.

Nyarko, R. O., Prakash, A., Kumar, N., Saha, P., & Kumar, R. (2021). Tuberculosis a globalized disease. Asian Journal of Pharmaceutical Research and Development, 9(1), 198-201.

Singh, M. K., Kumar, A., Kumar, R., Kumar, P. S., Selvakumar, P., & Chourasia, A. (2022). Effects of Repeated Deep Frying on Refractive Index and Peroxide Value of Selected Vegetable Oils. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 28-31.

Nyarko, R. O., Kumar, R., Sharma, S., Chourasia, A., Roy, A., & Saha, P. (2022). ANTIBACTERIAL ACTIVITY OF HERBAL PLANT-TINOSPORA CORDIFOLIA AND CATHARNTHUS ROSEUS.

Raj, A., Tyagi, S., Kumar, R., Dubey, A., & Hourasia, A. C. (2021). Effect of isoproterenol and thyroxine in herbal drug used as cardiac hypertrophy. Journal of Cardiovascular Disease Research, 204-217.

PURABISAHA, R. K., RAWAT, S. S. N., & PRAKASH, A. (2021). A REVIEW ON NOVEL DRUG DELIVERY SYSTEM.

Nyarko, R. O., Saha, P., Kumar, R., Kahwa, I., Boateng, E. A., Boateng, P. O., ... & Bertram, A. (2021). Role of Cytokines and Vaccines in Break through COVID 19 Infections. Journal of Pharmaceutical Research International, 33, 2544-2549.

KUMAR, R., SAHA, P., SARKAR, S., RAWAT, N., & PRAKASH, A. (2021). A REVIEW ON NOVEL DRUG DELIVERY SYSTEM. IJRAR-International Journal of Research and Analytical Reviews (IJRAR), 8(1), 183-199.

Kumar, R., Saha, P., Kumar, Y., Sahana, S., Dubey, A., & Prakash, O. (2020). A Review on Diabetes Mellitus: Type1 & Type2. World Journal of Pharmacy and Pharmaceutical Sciences, 9(10), 838-850.

Kumar, R., Saha, P., Pathak, P., Mukherjee, R., Kumar, A., & Arya, R. K. EVOLUTION OF TOLBUTAMIDE IN THE TREATMENT OF DIABETES MELLITUS. Jour. of Med. P’ceutical & Alli. Sci, 9.

SHAFQAT ZAIDI, R. K. MEHRA, Dr. SACHIN TYAGI, ROSHAN KUMAR ANUBHAV DUBEY. (2021). Effect of Kalahari Cactus Extract on Appetitte, Body Weight And Lipid Profile In Cafeteria Diet Induced Obesity In Experimental Animal. Annals of the Romanian Society for Cell Biology, 25(6), 13976-13987.

Tiwari, A., Singh, S., Dubey, A., & Singh, Y. (2021). A preliminary study on antihyperlipidemic activity of cinnamon oil in wistar rat. International Journal of Current Research, 13(03), 16741-16745.

Kumar, N., Dubey, A., Mishra, A., & Tiwari, P. (2020). Ethosomes: A Novel Approach in Transdermal Drug Delivery System. International Journal of Pharmacy & Life Sciences, 11(5).

Dubey, A., Tiwari, D., Singh, Y., & Prakash, O. (2021). Pankaj Singh. Drug repurposing in Oncology: Opportunities and challenges. Int J of Allied Med Sci and Clin Res, 9(1), 68-87.

Vigen R, Weideman RA, Reilly RF. Thiazides diuretics in the treatment of nephrolithiasis: are we using them in an evidence-based fashion? Int Urol Nephrol. 2011 Sep;43(3):813-9.

Carroll MF, Schade DS. A practical approach to hypercalcemia. Am Fam Physician. 2003 May 01;67(9):1959-66.

Loffing J. Paradoxical antidiuretic effect of thiazides in diabetes insipidus: another piece in the puzzle. J Am Soc Nephrol. 2004 Nov;15(11):2948-50.

CRAWFORD JD, KENNEDY GC. Chlorothiazid in diabetes insipidus. Nature. 1959 Mar 28;183(4665):891-2.

Burtscher M, Gatterer H, Faulhaber M, Burtscher J. Acetazolamide pre-treatment before ascending to high altitudes: when to start? Int J Clin Exp Med. 2014;7(11):4378-83.

Schmidl D, Schmetterer L, Garhöfer G, Popa-Cherecheanu A. Pharmacotherapy of glaucoma. J Ocul Pharmacol Ther. 2015 Mar;31(2):63-77

Rosenbaum A, Winter M. Are diuretics effective for Ménière`s disease? Medwave. 2018 Mar 28;18(2):e7188.

Tenny S, Patel R, Thorell W. StatPearls [Internet]. StatPearls Publishing; Treasure Island (FL): Mar 25, 2021. Mannitol

Witherspoon B, Ashby NE. The Use of Mannitol and Hypertonic Saline Therapies in Patients with Elevated Intracranial Pressure: A Review of the Evidence. Nurs Clin North Am. 2017 Jun;52(2):249-260

Ghannoum M, Gosselin S. Enhanced poison elimination in critical care. Adv Chronic Kidney Dis. 2013 Jan;20(1):94-101.

Prescott LF, Balali-Mood M, Critchley JA, Johnstone AF, Proudfoot AT. Diuresis or urinary alkalinisation for salicylate poisoning? Br Med J (Clin Res Ed). 1982 Nov 13;285(6352):1383-6.

Dubey Anubhav Ghosh Sekhar Niladry, Saxena Gyanendra Kumar, Purohit Debashis, Singh Shweta, (2022). Management implications for neurotoxic effects associated with antibiotic use. NeuroQuantology, 6(20), 304-328. doi: 10.14704/nq.2022.20.6.NQ22034.

Dubey, A., Ghosh, N. S., Rathor, V. P. S., Patel, S., Patel, B., &Purohit, D. (2022). Sars- COV-2 infection leads to neurodegenerative or neuropsychiatric diseases. International Journal of Health Sciences, 6(S3), 2184–2197. https://doi.org/10.53730/ijhs.v6nS3.5980.

Dubey A., Kumar R., Kumar S., Kumar N., Mishra A., Singh Y. and Tiwari M. (2020). Review on Vinpocetine, Int. J. of Pharm. & Life Sci., 11(5): 6590-6597.

Srivastava K., Tiwari M., Dubey A. and Dwivedi A. (2020). D-Pinitol - A Natural Phytomolecule and its Pharmacological effect, Int. J. of Pharm. & Life Sci., 11(5): 6609-6623.

Dubey, A., Tiwari, D., Singh, Y., & Prakash, O. (2021). Pankaj Singh. Drug repurposing in Oncology: Opportunities and challenges. Int J of Allied Med Sci and Clin Res, 9(1), 68-87.

Meher, C. P., Purohit, D., Kumar, A., Singh, R., & Dubey, A. (2022). An updated review on morpholine derivatives with their pharmacological actions. International Journal of Health Sciences, 6(S3), 2218–2249. https://doi.org/10.53730/ijhs.v6nS3.5983.

Patnaik, S., Purohit, D., Biswasroy, P., Diab, W. M., & Dubey, A. (2022). Recent advances for commedonal acne treatment by employing lipid nanocarriers topically. International Journal of Health Sciences, 6(S8), 180–205. https://doi.org/10.53730/ijhs.v6nS8.9671

-Anubhav Dubey, Deepanshi Tiwari, Kshama Srivastava, Om Prakash and Rohit Kushwaha. A discussion on vinca plant. J Pharmacogn Phytochem 2020;9(5):27-31.

kumar, R., Saha, P., Nyarko, R., Lokare, P., Boateng, A., Kahwa, I., Owusu Boateng, P., & Asum, C. (2022). Effect of Covid-19 in Management of Lung Cancer Disease: A Review. Asian Journal of Pharmaceutical Research and Development, 10(3), 58-64. https://doi.org/https://doi.org/10.22270/ajprd.v10i3.113.

Rasheed Khushnuma, Gupta Dakshina , Dubey Anubhav, Singh Yatendra , A REVIEW ON β-ESCIN, Indian Journal of Medical Research and Pharmaceutical Sciences, 2021;8(1),10-16. DOI: https://doi.org/10.29121/ijmrps.v8.i1.2020.2.

Dubey Anubhav, Kumar Abhay, Peeyush, Singh Jitendra, Medicinal property of Callistemon viminalis, International Journal of Pharmacognosy and Life Science 2021; 2(2): 15-20. DOI: https://doi.org/10.33545/27072827.2021.v2.i2a.35.

Kumari Pushpa, Kumar Santosh, Shukla Bhanu Pratap, Dubey Anubhav, An overview on breast cancer,International Journal of Medical and all body Health Research www.allmedicaljournal,2021;2(3),59-65.www.allmedicaljournal.com.

Yadav Priyanka, Dubey Anubhav, Formulation and characterization of anti-epileptic drug transdermal patch for enhance skin permeation, European Journal of Biomedical and Pharmaceutical Sciences 2021: 8, (9), 784-790. http://www.ejbps.com.

Prerna, Dubey Anubhav, Gupta Ratan, Nanoparticles: An Overview, Drugs and Cell Therapies in Haematology2021;10(1),1487-1497.

Rajeshwari Shweta Raj, Shukla Dr. Prashant, Dubey Anubhav, Delivery of repurposed drugs for cancer: opportunities and challenges,European Journal of Pharmaceutical and Medical Research 2021,8(9), 271-281. www.ejpmr.com.

Saha Purabi Dubey Anubhav, Kumar Dr. Sanjay, Kumar Roshan, Evaluation of Enzyme Producing K. Pneumoniae and Their Susceptibility to Other Anti-Biotics, International Journal of Innovative Science and Research Technology 2022; 7(5), 351-353. www.ijisrt.com.

Panda Braja Bihari, Patnaas, Swastik, Purohit Debashish, Das Shubhashree, Dubey Anubhav, Impact of sodium starch glycolate on Physico-chemical characteristics of mouth dissolving film of Fexofenadine, Neuro Quantology2022; 20(6) 7604-7613. doi: 10.14704/nq.2022.20.6.NQ22759.

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Published

2022-08-31

How to Cite

Pandey, M., Singh, A., Namrata, Agnihotri, N., Kumar, R., Saha, P., Pandey, R. P., Kumar, A., & Shiwangi. (2022). Clinical Pharmacology & Therapeutic uses of Diuretic Agents: A Review. Journal for Research in Applied Sciences and Biotechnology, 1(3), 11–20. https://doi.org/10.55544/jrasb.1.3.3

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