A Review on Stem Cells: A New Toll in Diseases Therapy

Abdul Qadeer Baseer; Shafiqullah Mushfiq; Mohammad Tahir Omid

doi:10.55544/jrasb.2.1.1

Authors

Abdul Qadeer Baseer Department of Biology, Faculty of Education, Kandahar University, Kandahar, AFGHANISTAN
Shafiqullah Mushfiq Department of Biology, Faculty of Education, Kandahar University, Kandahar, AFGHANISTAN.
Mohammad Tahir Omid Department of Biology, Faculty of Education, Urozgan Higher Education Institute, Urozgan, AFGHANISTAN.

DOI:

https://doi.org/10.55544/jrasb.2.1.1

Keywords:

Stem cells, Disease modelling, Regenerative medicine, Drug discovery, Cytotoxicity

Abstract

Stem cells are known as special somatic cell types that have the ability to self-renew and differentiate into various types of cells. They are categorized into two major groups such as embryonic stem cells and adult stem cells. Embryonic stem cells are pluripotent, which have the potency to differentiate into almost all cell types and grow up from the mesoderm, endoderm, and ectoderm germ layers at the beginning stages of embryo. While adult stem cells can be pluripotent or multipotent, which can differentiate into the family of a closely related cells. Over few decades, researchers have been studying and exploring new ways to treat different types of diseases like Parkinson’s and Alzheimer’s disease by using stem cells. Hence, embryonic and adult stem cells have been widely used in stem cell therapy. Here, we elaborate the problems of using embryonic stem cells and adult stem cells in stem cell therapy and its possible solutions, and discuss the applications of both stem cells types in biology-based field including disease modelling, regenerative medicine, drug discovery and cytotoxicity studies.

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References

Nadiya P. Advances in Stem Cell Technologies for Disease Therapy: A Current Review. Ann Adv Biomed Sci 2018, 1(2): 000107.

Kalra, K., & Tomar, P. (2014). Stem cell: basics, classification and applications. American Journal of Phytomedicine and Clinical Therapeutics, 2(7), 919-930.

Ding, D. C., Chang, Y. H., Shyu, W. C., & Lin, S. Z. (2015). Human umbilical cord mesenchymal stem cells: a new era for stem cell therapy. Cell transplantation, 24(3), 339-347.

Laflamme, M. A., Chen, K. Y., Naumova, A. V., Muskheli, V., Fugate, J. A., Dupras, S. K., ... & O'Sullivan, C. (2007). Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nature biotechnology, 25(9), 1015.

Kim, J. H., Auerbach, J. M., Rodríguez-Gómez, J. A., Velasco, I., Gavin, D., Lumelsky, N., ... & McKay, R. (2002). Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature, 418(6893), 50.

Lo, B., & Parham, L. (2009). Ethical issues in stem cell research. Endocrine reviews, 30(3), 204-213.

Ikehara, S. (2013). Grand challenges in stem cell treatments. Frontiers in cell and developmental biology, 1, 2.

Diederichs, S., Shine, K. M., & Tuan, R. S. (2013). The promise and challenges of stem cell‐based therapies for skeletal diseases: stem cell applications in skeletal medicine: potential, cell sources and characteristics, and challenges of clinical translation. Bioessays, 35(3), 220-230.

Zimmermann, S., Glaser, S., Ketteler, R., Waller, C. F., Kingmuller, U, and Martens, U. M. (2004). Effects of telomerase modulation in human hematopoietic progenitor cells. Stem Cells, 741-749.

Liu, S., Zhou, J., Zhang, X., Liu, Y., Chen, J., Hu, B., Song, J., Zhang, Y. (2016). Strategies to Optimize Adult Stem Cell Therapy for Tissue Regeneration. International Journal of Molecular Sciences, 1-16.

Mariano, E. D., Texixeira, M. J., Marie, S. K N., Lepski G. (2015). Adult Stem Cells in Neural Repair: Current options, limitations and perspectives. World Journal of Stem Cells, 477-482.

Avior, Y., Sagi, I., & Benvenisty, N. (2016). Pluripotent stem cells in disease modelling and drug discovery. Nature Reviews Molecular Cell Biology, 17(3), 170.

Piganeau, M., Ghezraoui, H., De Cian, A., Guittat, L., Tomishima, M., Perrouault, L., … Holmes, M. C. (2013). Cancer translocations in human cells induced by zinc finger and TALE nucleases. Genome Research, 23(7), 1182–1193.

Martinez, R. A., Stein, J. L., Krostag, A.-R. F., Nelson, A. M., Marken, J. S., Menon, V., … Geschwind, D. H. (2015). Genome engineering of isogenic human ES cells to model autism disorders. Nucleic Acids Research, 43(10), e65–e65.

Briggs, J. A., Mason, E. A., Ovchinnikov, D. A., Wells, C. A., and Wolvetang, E. J. (2013). Concise review: new paradigms for down syndrome research using induced pluripotent stem cells: tackling complex human genetic disease. Stem Cells Transl. Med, 175-184.

Nguyen, H. N., Byer, B., Cord, B., Shcheglovitov, A., Byrne, J., Gujar, P., et al. (2011). LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. Cell Stem Cell, 267-280.

Bruin, J. E., Saber, N., Braun, N., Fox, J. K., Mojibian, M., Asadi, A., … Swiss, V. A. (2015). Treating diet-induced diabetes and obesity with human embryonic stem cell-derived pancreatic progenitor cells and antidiabetic drugs. Stem Cell Reports, 4(4), 605–620.

Salguero-Aranda, C., Tapia-Limonchi, R., Cahuana, G. M., Hitos, A. B., Diaz, I., Hmadcha, A., … Tejedo, J. R. (2016). Differentiation of mouse embryonic stem cells toward functional pancreatic β-cell surrogates through epigenetic regulation of Pdx1 by nitric oxide. Cell Transplantation, 25(10), 1879–1892.

Shroff, G., & Gupta, R. (2015). Human embryonic stem cells in the treatment of patients with spinal cord injury. Annals of Neurosciences, 22(4), 208.

Li, Y., Tsai, Y., Hsu, C., Erol, D., Yang, J., Wu, W., et al. (2012). Long term safety and efficacy of human-induced pluripotent stem cells (iPS) grafts in a preclinical model of retinitis pigmentosa. Mol. Med., 1312-1319.

Kerns, W. D., Parkov, K. L., Donofrio, D. J., Gralla, E. J., Swenberg, J. A. (1983). Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure. Cancer Res, 4382-4392.

Fang, Y., & Eglen, R. M. (2017). Three-dimensional cell cultures in drug discovery and development. SLAS DISCOVERY: Advancing Life Sciences R&D, 22(5), 456–472.

Taha, M. F., Valojerdi, M. R., Hatami, L., & Javeri, A. (2012). Electron microscopic study of mouse embryonic stem cell-derived cardiomyocytes. Cytotechnology, 64(2), 197–202.

Genschow, E., Spielmann, H., Scholz, G., Pohl, I., Seiler, A., Clemann, N., … Becker, K. (2004). Validation of the embryonic stem cell test in the international ECVAM validation study on three in vitro embryotoxicity tests. ATLA-NOTTINGHAM-, 32, 209–244.

Seiler, A., Visan, A., Buesen, R., Genschow, E., and Spielmann, H. (2004). Improvement of an in vitro stem cell assay for development toxicity: the use of molecular endpoints in the embryonic stem cell test. Reprod. Toxicol, 231-240.