Role of Pyrimidine Derivatives in the Treatment of Cancer

Prakash Pralhad Sarwade; K. M. Srinandhinidevi; Kiran Dangwal; Chandresh Maurya; Mihir Otia; Subham kumar; Jay Prakash; Kavita Narayan Gaisamudre (Sarwade)

doi:10.55544/jrasb.3.5.19

Authors

Prakash Pralhad Sarwade Associate Professor and Head, Department of Botany, Shikshan Maharshi Guruvarya R. G. Shinde Mahavidyalaya, Paranda Dist. Dharashiv (Osmanabad) 413 502, (M.S.) INDIA.
K. M. Srinandhinidevi Assistant Professor, Department of Zoology, Quaid-E-Millath Government College for Women (Autonomous), Chennai -02, INDIA.
Kiran Dangwal Assistant Professor, Alpine College of Management and Technology Dehradun, INDIA.
Chandresh Maurya Department Of Pharmacognosy, Faculty of Pharmacy PK University Shivpuri MP 473665, INDIA.
Mihir Otia MBA, University of East London, London, UNITED KINGDOM.
Subham kumar Assistant Professor, Vidya Jyoti College of Pharmacy Bazpur, INDIA
Jay Prakash Clinical Pharmacologist, Department of Clinical Pharmacology Paras Health Gurugram, INDIA
Kavita Narayan Gaisamudre (Sarwade) Assistant Professor, Department of Botany, Shriman Bhausaheb Zadbuke Mahavidyalaya, Barshi Tal. Barshi, Dist- Solapur 413 401 Maharashtra, INDIA

DOI:

https://doi.org/10.55544/jrasb.3.5.19

Keywords:

Pyrimidine, cancer, heterocycle, cytotoxicity

Abstract

The study of the chemistry of pyrimidines is contributing to the expansion of research into the therapeutic applications of these compounds. In the field of medicinal chemistry, the sheer number of pyrimidine synthesis methods and reactions that are available opens up a world of possibilities. These investigations have been inspired by the fact that pyrimidines can be used as building blocks for a wide variety of compounds that have a physiological effect. The pyrimidine ring and its fused derivatives, which include pyrazolo[3,4-d]pyrimidine, pyrido[2,3-d]pyrimidine, quinazoline, and furo[2,3-d]pyrimidine, have garnered a great deal of attention due to the extensive variety of biological potential that they possess. In addition, fused pyrimidines are considered to be bioisosteres with purines. As a consequence of this, numerous substances, such as pyrimidine and derivatives of fused pyrimidine, have demonstrated promising anticancer potential. Pyrimidine compounds have been shown to possess a number of beneficial qualities, including antibacterial, anticancer, anti-inflammatory, antidiabetic, and analgesic effects. The purpose of this study is to shed light on the anticancer significance of certain fused pyrimidine derivatives and privileged pyrimidines through the use of various types of inhibition. Additionally, the study reveals structure-activity relationships and provides specifics regarding the synthetic compounds that were utilized in the construction of these scaffolds. The hope is that this research will assist medicinal chemists in the development of highly selective pyrimidine anticancer agents. The focus of this review article is on recent research on synthetic pyrimidine compounds that have anticancer effects. Additionally, the paper examines the chemistry and biological activities of pyrimidines.

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