Formulation & Evaluation of Anti Migrane Mouth Dissolving Tablet

Authors

  • Jyotsna Upadhyay Assistant Professor, Department of Pharmacy, Shree Dev Bhoomi Institute of Education Science and Technology, Dehradun, 248007, Dehradun, Uttarakhand, INDIA.
  • Amle Vandana Sonaji Assistant Professor, Shri Bhairavnath Nisarg Mandal, Hatta, Basmat, Hingoli, Maharashtra-431542, INDIA.
  • Farha Naaz Assistant Professor, Department of Pharmacy, Shree Dev Bhoomi Institute of Education Science and Technology, Dehradun, 248007, Dehradun, Uttarakhand, INDIA.

DOI:

https://doi.org/10.55544/jrasb.3.2.40

Keywords:

Rizatriptan, ODDS, Hardness test, LOD, LOQ, Tablet formulation

Abstract

The objective of this study is to improve the safety, efficacy, and rate of action of the existing molecule by utilising novel techniques to the administration of medication. This will be accomplished by the application of novel approaches. Orally disintegrating pills containing rizatriptan benzoate were made by the direct compression technique in order to provide migraine sufferers with a more expedient manner of gaining relief from their condition. For the purpose of this inquiry, a 32-factororial design method was utilised, and eight different formulations were examined for each of the super disintegrants that were explored. There were a number of tests that were performed on the batches of tablets that were manufactured. These tests included weight variation, hardness, friability, wetting time, invitro dispersion time, drug content, and invitro dissolution. A UV spectrophotometric approach that is easy, sensitive, rapid, accurate, cost-effective, and repeatable was created in order to identify the dose form of Rizatriptan Benzoate tablets. This method was designed in order to determine the dose form. It has been determined that rizatriptan benzoate has the maximum absorbance at a wavelength of 225 nm, and its molar absorption is measured to be 1.619 Ao. According to Beer's law, the application of the law was observed between 1 and 10 μg/ml. In order to validate the conclusions of the investigation, statistical analysis and recovery studies were carried out. In order to validate the method, a number of various criteria were utilised. These criteria included linearity, accuracy, limit of detection (LOD), limit of quantification (LOQ), Sandell's sensitivity, and specificity were among the criteria that were utilised. The practice of determining the regular dosage of Rizatriptan Benzoate in both tablet and bulk forms was found to be one that is accurate and precise via the utilisation of the preferred method. This was identified through the utilisation of the recommended method. A time period ranging from fifteen to thirty seconds was required for the optimised formulation to be distributed throughout the body. Furthermore, it demonstrated a greater water absorption ratio and released 99.60% of the medication over a period of two minutes and fifteen seconds. This was in addition to everything else that it shown.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Bi, Y., Sunada, H., Yonezawa, Y., Danjo, K., Otsuka, A., & Iida, K. (1996). Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity. Chemical and pharmaceutical bulletin, 44(11), 2121-2127.

Fu, Y., Yang, S., Jeong, S. H., Kimura, S., & Park, K. (2004). Orally fast disintegrating tablets: developments, technologies, taste-masking and clinical studies. Critical Reviews™ in Therapeutic Drug Carrier Systems, 21(6).

Shukla, S., Rawat, N., Rana, S., Rana, V., Mittal, C., Kumar, R., & Sood, P. (2023). Clinical Features Present, Past & Future Prospective of Monkey Pox: A Orthopoxvirus. Journal for Research in Applied Sciences and Biotechnology, 2(3), 134-146.

Kumar, R., Nagar, S., Haider, S., Sood, U., Ponnusamy, K., Dhingra, G. G., ... & Lal, R. (2022). Monkey pox virus (MPXV): phylogenomics, host-pathogen interactome, and mutational cascade. bioRxiv, 2022-07.

Hoffmann, E. M., Breitenbach, A., & Breitkreutz, J. (2011). Advances in orodispersible films for drug delivery. Expert opinion on drug delivery, 8(3), 299-316.

Gopal, R. K., Raj, P. P., Dukare, A., & Kumar, R. (2022). Metabolic Engineering of Methanogenic Archaea for Biomethane Production from Renewable Biomass. In Biomethane (pp. 43-60). Apple Academic Press.

Das, S., Singh, V. D., Bind, A., Anamika, A., Gupta, S. P., & Kumar, R. (2022). Evaluation of antiulcer, antioxidant potency of manuka honey and cinnamon powder mixture in Wistar rats using experimental rat models. International Journal of Health Sciences, 6, 6259-6268.

Wongkuna, S., Ambat, A., Ghimire, S., Mattiello, S. P., Maji, A., Kumar, R., ... & Scaria, J. (2024). Identification of a microbial sub-community from the feral chicken gut that reduces Salmonella colonization and improves gut health in a gnotobiotic chicken model. Microbiology Spectrum, e01621-23.

Bi, Y. X., Sunada, H., Yonezawa, Y., & Danjo, K. (1999). Evaluation of rapidly disintegrating tablets prepared by a direct compression method. Drug development and industrial pharmacy, 25(5), 571-581.

Kumar, R., Sood, P., Shaik, R., Singh, H. K., & Verma, A. (2023). A Brief Description of Different Types of Cancers and Role of Some Herbs & Bioactive Compounds in Lung Cancer Management. Journal for Research in Applied Sciences and Biotechnology, 2(4), 32-47.

Verma, S., Suman, P., Mandal, S., Kumar, R., Sahana, N., Siddiqui, N., & Chakdar, H. (2023). Assessment and identification of bioactive metabolites from terrestrial Lyngbya spp. responsible for antioxidant, antifungal, and anticancer activities. Brazilian Journal of Microbiology, 54(4), 2671-2687.

Kumar, R., Nirala, R. K., Ade, R. P., & Sonaji, A. V. (2023). Uses of AI in Field of Radiology-What is State of Doctor & Patients Communication in Different Disease for Diagnosis Purpose. Journal for Research in Applied Sciences and Biotechnology, 2(5), 51-60.

Gohel, M., Patel, M., Amin, A., Agrawal, R., Dave, R., & Bariya, N. (2004). Formulation design and optimization of mouth dissolve tablets of nimesulide using vacuum drying technique. AAPs PharmSciTech, 5, 10-15.

Bajpai, S., Bajpai, Y. K., Awasthi, A., Mittal, C., Tariyal, K., Sood, P., & Kumar, R. (2023). Recent Approaches of Intranasal to Brain Drug Delivery System. Journal for Research in Applied Sciences and Biotechnology, 2(3), 173-182.

Kumar, G., Dhariwal, S., Kumar, R., Yadav, A. R., Amponsah, E., & Singh, P. K. (2022, February). Damage Identification of Beam Structure Using Discrete wavelet transform. In 2022 2nd International Conference on Artificial Intelligence and Signal Processing (AISP) (pp. 1-5). IEEE.

Kumar, R., Rauwel, P., & Rauwel, E. (2021). Nanoadsorbants for the Removal of Heavy Metals from Contaminated Water: Current Scenario and Future Directions. Processes 2021, 9, 1379.

Shekhar, S., Kumar, A., Rana, V., Kumar, R., Mittal, C., & Tariyal, K. (2023). Recent Approaches of Matrix Release Tablet in NDDS System. Journal for Research in Applied Sciences and Biotechnology, 2(3), 64-71.

Comoglu, Tansel, and Emine Dilek Ozyilmaz. "Orally disintegrating tablets and orally disintegrating mini tablets–novel dosage forms for pediatric use." Pharmaceutical Development and technology 24, no. 7 (2019): 902-914.

Shukla, S., Rawat, N., Rana, S., Rana, V., Mittal, C., Kumar, R., & Sood, P. (2023). Clinical Features Present, Past & Future Prospective of Monkey Pox: A Orthopoxvirus. Journal for Research in Applied Sciences and Biotechnology, 2(3), 134-146.

Mittal, C., Amle, V. S., Kumar, R., Sood, P., Uniyal, A., & Singh, H. (2023). Recent Advancement in Ocular Drug Delivery System: A Systematic Review. Journal for Research in Applied Sciences and Biotechnology, 2(3), 238-249.

Kumar, R., Sood, P., Nirala, R. K., Christian, A., Nyarko, R. O., Boateng, E. A., ... & Orlando, V. K. (2023). Plant & its Bioactive Components Uses in Cardio-Potential Diseases: A Sectional Study for Different Herbs. Journal for Research in Applied Sciences and Biotechnology, 2(5), 61-71.

Downloads

Published

2024-05-25

How to Cite

Upadhyay, J., Sonaji, A. V., & Naaz, F. (2024). Formulation & Evaluation of Anti Migrane Mouth Dissolving Tablet. Journal for Research in Applied Sciences and Biotechnology, 3(2), 233–241. https://doi.org/10.55544/jrasb.3.2.40

Issue

Section

Articles

Most read articles by the same author(s)