Polymorphisms of IL-1B And IL-10 Genes in Abortion Due to Toxoplasmosis

Basheer Abd. Nasralla; Nazar Sh. Mohammed; Salwa S. Muhsen Muhsen

doi:10.55544/jrasb.3.2.21

Authors

Basheer Abd. Nasralla 1,3Medical Technical Institute, 2Colleges of Health and Medical Technology, IRAQ.
Nazar Sh. Mohammed Meddle Technical University, Baghdad (MTU), IRAQ.
Salwa S. Muhsen 1,3Medical Technical Institute, 2Colleges of Health and Medical Technology, IRAQ.

DOI:

https://doi.org/10.55544/jrasb.3.2.21

Keywords:

Polymorphisms, IL-1B, IL-10 genes, abortion, Toxoplasmosis

Abstract

Ninety whole blood samples were collected from women attended Ibn-abalady Hospital/Baghdad city. 60 samples were taken from aborted women and 30 samples were taken from healthy women as a control group, from period 1^st October 2022 to 2^nd may 2023. According the results, the mean age of aborted women who attacked with toxoplasmois groups were 31.50 ±1.05 versus 34.53±2.09 of control groups with non-statistical differences (P-value=0.2). The results also observed the most cases of 3 (30.0%) among aborted women were at the (27-36) years with 27/60 (73.0%) , while the less cases of toxoplasmosis among aborted women were at the age > 46 years with 3/60 (30.0%),These differences statistically were non-significant (P-value=0.07). The results also observed there were equal cases of toxoplasmosis of women who habited urban and rural regions 30 /60 (66.7%),30 (66.7%) respectively. the levels of IgM (2.01±0.15, 0.13±0.03) and IgG (14.24±0.91, 0.09±0.02) were higher in levels among pregnant women than control groups respectively, these differences in the levels was highly significant (p ≤0.001,≤ 0.001) respectively. the levels of IL-IB (24.32±1.04, 4.64±0.36) and IL-10 (60.67±3.46, 5.61±0.36) were higher in levels among aborted women than control groups respectively, these differences in the levels was highly significant. there were a significant differences in the levels of IgM () among aborted betwen the duration of pregnancy with P-value=0.03,Althogh the the levels of IgG were increased in levls among aborted women during the the first, second and third (14.40±1.41, 15.16±1.77, 12.86±1.62) above the normal range (≥1) respectively. there were non significant differences in the levels of both IL-1B and IL-10 among aborted women during the the first, second and third simister although there were increased in the levels of both IL-1B and IL-10.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

French, T. Düsedau, H. P. and Steffen, J. et al., Neuronal impairment following chronic Toxoplasma gondii infection is aggravated by intestinal nematode challenge in an IFN-γ-dependent manner, French et al. Journal of Neuroinflammation (2019) 16:159, doi.org/10.1186/s12974-019-1539-8.

Kapse, B. Hongwei Zhang, H. and Nicole Affinass, N. et al., Age-dependent rise in IFN-γ competence undermines effective type 2 responses to nematode infection, M ucosal Immunology (2022) 15:1270–1282; https://doi.org/10.1038/s41385-022-00519-6.

Deng, S. Graham, M. L. and Chen, Xian-Ming, The Complexity of Interferon Signaling in Host Defense against Protozoan Parasite Infection, Pathogens 2023, 12, 319. https://doi.org/10.3390/pathogens12020319.

Wesołowski , R. Marta Pawłowska , M. Smoguła, M. and Szewczyk-Golec, K. Advances and Challenges in Diagnostics of Toxoplasmosis in HIV-Infected Patients Pathogens 2023, 12, 110. https://doi.org/10.3390/pathogens12010110.

Cubas-Vega, N. Del-Tejo, P. L. and Baia-da-Silva, D. C. et al., Early Antiretroviral Therapy in AIDS Patients Presenting With Toxoplasma gondii Encephalitis Is Associated With More Sequelae but Not Increased Mortality, Front. Med. 9:759091. doi: 10.3389/fmed.2022.759091.

Olaniran O, Olaniran OO, Adenekan NP, et al. Prevalence and co-infection of Toxoplasma gondii and Human Immunodeficiency Virus (HIV) infection among women of child-bearing age in Osun state Nigeria. Int Clin Pathol J. 2022;9(1):35‒40. DOI: 10.15406/icpjl.2022.09.00206.

Purnamasari, D. Satiti, S. Pambudi , D. and Kraksono, D. P-OT028. Clinical features of HIV patients with toxoplasmosis infection at Dr. Sardjito General Hospital Yogyakarta, Clinic. Neurophysio. Vol, 132, Iss, 8, August 2021, Pages e129-e130.

Feleke , D. G. Gebreweld , A. and Gashaw Zewde, G. Toxoplasmosis in Pregnant Women and HIV/AIDS Patients in Ethiopia: A Systematic Review and Meta-Analysis, Journal of Parasitology Research Vol 2019 ID 4670397, 8 p. doi.org/10.1155/2019/467039.

Najeeb, M. A. Amjed Qays, A. and Alqaisi. A. Laminin Is a Promising Predictive Biomarker for Acute and Chronic Toxoplasmosis, The Egyptian Journal of Hospital Medicine (October 2022) Vol. 89, Page 5083- 5087.

PASVENSKAITE1, A. LIUTKEVICIENE, R. and GRETA GEDVILAITE, G. et al., Impact of IL-10 Promoter Polymorphisms and IL-10 Serum Levels on Advanced Laryngeal Squamous Cell Carcinoma and Survival Rate. CANCER GENOMICS & PROTEOMICS 18: 53-65 (2021) doi:10.21873/cgp.20241.

National center for biochemically informatics, IL1B interleukin 1 beta [ Homo sapiens (human), Gene ID: 3553, updated on 9-May-2023.

National center for biochemically informatics, Il10 interleukin 10 [ Mus musculus (house mouse) Gene ID: 16153, updated on 9-May-2023.

Albosale , A. H. , Mashkina, E. V. Association Between Promoter Polymorphisms of IL-1Β, IL-4 and IL-6 Genes and a Viral Load Infected Women with Human Papillomavirus, Journal of Reproduction & Infertility Volume 22, Issue no. 2 http://dx.doi.org/10.18502/jri.v22i2.5794.

Salman, O. A Novel Single Nucleotide Polymorphism of Interleukin-10 Gene is Linked to Type 2 Diabetes Mellitus in Iraqi Patients with Toxoplasmosis(Conference Paper ), Iraqi Journal of Pharmaceutical Sciences (IJPS) is the official journal of, Vol. 31 No. Suppl. (2022): Iraqi J Pharm Sci.

ZGHAIR, ABDULRAZZAQ NEAMAH, NAZAR SH MOHAMMED, and SALWA S. MUHSIN. "Change in CRT gene sequence of Plasmodium falsiparum as a chloroquen resistant in Iraqi patients." International Journal of Pharmaceutical Research (09752366) 12.2 (2020).