Study of Many Biochemical and Oxidative Stress Variables in Patients with Atherosclerosis in Kirkuk City

Elaf Erfan Khalaf Al-Hadidi; Wedad Mahmood Lahmood Al-Obaidi

doi:10.55544/jrasb.1.3.26

Authors

Elaf Erfan Khalaf Al-Hadidi Department of Biology, College of Science, University of Kirkuk, IRAQ.
Wedad Mahmood Lahmood Al-Obaidi Department of Biology, College of Science, University of Kirkuk, IRAQ.

DOI:

https://doi.org/10.55544/jrasb.1.3.26

Keywords:

Atherosclerosis, cardiac troponin T, insulin, fasting blood sugar, hemoglobin A1C, asprosin, body mass index

Abstract

The current study was designed to detect the role of a number of chemical variables represented by fasting blood sugar, hemoglobin A1c and insulin and oxidative stress factors in atherosclerosis patients. The present study involved (70) blood samples aged between (35-65) years the first group involved (40) blood samples from atherosclerosis patients and the second group involved (30) blood samples from healthy individuals, the samples were collected from respondents at Kirkuk General Hospital and Azadi Teaching Hospital in Kirkuk for a while 2021/12/22 to 2022/2/8 and the samples were taken after eight hours of fasting and all the information was taken from the reviewers by means of a questionnaire that included age, body mass index, systolic pressure and diastolic pressure and the results were as follows: significant increase in body mass index in the group of atherosclerosis patients compared to a healthy control group at a significant level (p 0.05) and 55% of them had elevated systolic pressure rate and 40% of them had high diastolic pressure ,the results from the current study show a significant increase in the concentration of asprosin compared to the control group at a significant level (p 0.05),the results of cardiac troponin(t) show a significant increase in the concentration of troponin in the patients of atherosclerosis compared to the control group at a significant level (p 0.05).

The results of the study biochemical variables have shown significant increase in fasting blood sugar in the group of atherosclerosis patients compared to a control group at a significant level (p 0.05) and the results of glycated hemoglobin Test (A1c) showed a significant increase in the group of atherosclerosis patients compared to a control group at a significant level (p 0.05) and the results of insulin showed a significant increase in the group of atherosclerosis patients compared to a control group at a significant level (p 0.05).

While the results of the study of the oxidative stress which included the glutathione and malondialdehyde there was insignificant reduction in serum concentration of GSH in atherosclerosis patients at a significant level (p 0.05) compared to a control group, and it has also been noted that was a significant increase in serum concentration of MDA in the atherosclerosis patients compared to a control group at a significant level (p 0.05).

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