To Identify Drug-Drug Interaction in Cardiac Patients in Tertiary Care Hospitals

Amreen Sultana; Malvika Singh; Ajay Kumar; Roshan Kumar; Purabi Saha; Ravi Shankar Kumar; Devinder Kumar

doi:10.55544/jrasb.1.3.20

Authors

Dr. Amreen Sultana Assistant Professor, Doctor of Pharmacy/Pharmacy Practice, Malla Reddy College of Pharmacy, Affiliated to Osmania University, Hyderabad, INDIA.
Malvika Singh Assistant Professor, M. Pharm Pharmacology, Malla Reddy College of Pharmacy, Affiliated to Osmania University, Hyderabad, INDIA.
Ajay Kumar Research Scholar, Department of Zoology, DSB Campus Kumaun University, Nainital, INDIA.
Roshan Kumar Department of Pharmacology, Dev Bhoomi Institute of Pharmacy and Research, Dehradun-248007, Uttarakhand, INDIA.
Purabi Saha Department of Pharmacy, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun -248007, Uttarakhand, INDIA.
Ravi Shankar Kumar Associate Professor, Shaheed Bhagat Singh Polytechnic and Pharmacy College, Patti, Punjab, INDIA.
Devinder Kumar Assistant Professor, Department of Pharmacology, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Punjab, INDIA.

DOI:

https://doi.org/10.55544/jrasb.1.3.20

Keywords:

Drug, Drug interaction, Patients Care, Cardiac disease, Case reports

Abstract

The potential for drug-drug interactions (pDDIs) is higher with cardiac medications, and reports of pDDIs in cardiovascular patients are more common. Multimorbidity, a greater number of drugs prescribed, longer hospital stays, complexity of disease, physiological changes with advancing age or conditions like renal failure, shock, hepatic disease like cirrhosis or acute viral hepatitis, stages of disease, and the influence of heart disease on drug metabolism make patients with CVD especially susceptible to DDIs. Our research found that pDDIs occurred at a much higher rate than expected in the Cardiology Division. Incidence of pDDIs was observed to rise with age, polypharmacy, and duration of hospital stay; pDDIs were also more common in males than females. Most of the interactions were of a pharmacodynamic character and were considered to be quite serious. Most pDDIs involved aspirin and clopidogrel, then aspirin and enalapril, and finally enalapril and enalapril. The surveillance of pDDIs in cardiac inpatients may benefit from the creation of such a database in hospitals.

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