Cascabela thevetia Ethnobotanical, Phytochemistry, Pharmacological Activities and Medicinal Uses: A Detailed Study

Prakash Pralhad Sarwade; Chandresh Maurya; Navin Chandra Pant; Manisha Rai; Neha Bhakuni; Vikas Lalit Gupta; Jay Prakash; Kavita Narayan Gaisamudre (Sarwade)

doi:10.55544/jrasb.3.5.22

Authors

Prakash Pralhad Sarwade Associate Professor and Head, Department of Botany, Shikshan Maharshi Guruvarya R. G. Shinde Mahavidyalaya, Paranda Dist-Dharashiv (Osmanabad) 413502, (M.S.) INDIA.
Chandresh Maurya Faculty of Pharmacy, PK University Shivpuri MP 473665, INDIA.
Navin Chandra Pant Associate Professor, Faculty of Pharmaceutical Sciences, Amrapali University, Haldwani Nainital, INDIA.
Manisha Rai Assistant Professor, Devine College of Pharmacy, INDIA.
Neha Bhakuni Assistant Professor, Rudupur College of Management and Technology, INDIA.
Vikas Lalit Gupta Assistant Professor, Department of Biotechnology, Viva College of Arts Commerce and Science, Virar West, Palghar-401303, INDIA.
Jay Prakash Clinical Pharmacologist, Department of Clinical Pharmacology, Paras Health Gurugram, INDIA.
Kavita Narayan Gaisamudre (Sarwade) Assistant Professor, Department of Botany, Shriman Bhausaheb Zadbuke Mahavidyalaya, Barshi Tal. Barshi, Dist- Solapur 413 401 Maharashtra, INDIA.

DOI:

https://doi.org/10.55544/jrasb.3.5.22

Keywords:

Cascabela thevetia, ethnobotanical, phytochemistry, pharmacological activities

Abstract

There are a few different names for the member of the Apocynaceae family known as Cascabela thevetia. Some of these names include digoxin, lucky nut, and yellow oleander. The lovely and evergreen Cascabela thevetia is a dicotyledonous shrub that is known for its evergreen nature. There are a number of countries in Central and South America, as well as a number of Asian nations, where the Cascabela thevetia plant is indigenous. These countries include India and Sri Lanka. The Cascabela thevetia plant has been found to have a wide variety of secondary metabolites, such as alkaloids, flavonoids, steroids, terpenoids, tannins, saponins, and cardiac glycosides. These plants include a number of cardiac glycosides, including neriifolin, thevetin A, thevetin B, and oleandrin, and each and every one of them is dangerous. The leaves of the plant are used in traditional medicine not just for their alleged medicinal benefits, but also for their diuretic and cardiotonic effects. The pharmacological activity of a number of plant components, including seeds, flowers, bark, fruits, and leaves, has been reported in a number of different experiments. It is common for T. peruviana to be the cause of toxicological emergencies in tropical and subtropical climates all over the world. Numerous cardiac glycosides, including neriifolin, oleandrin, thevetin A, and thevetin B, are discovered in this potentially hazardous plant. These glycosides are only a few examples. After consuming oleander, some of the symptoms that may manifest themselves include hyperkalaemia, nausea, vomiting, diarrhoea, and abdominal pain. Oliander can also cause diarrhoea. The purpose of this review is to provide a comprehensive data collection that includes information on morphology, cultivation and propagation, distribution, phytochemistry, traditional uses, and pharmacological qualities.

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