Review of Virulence Factors in Candida

Mohammed Sami Farhan; Bilal Ahmed Abdullah; Ali Esam Mamdwooh; Rand Salwan Numan

doi:10.55544/jrasb.3.2.15

Authors

Mohammed Sami Farhan Department of Biology, College of Sciences, Tikrit University, IRAQ.
Bilal Ahmed Abdullah Department of Biology, College of Sciences, Tikrit University, IRAQ.
Ali Esam Mamdwooh Department of Biology, College of Sciences, Tikrit University, IRAQ.
Rand Salwan Numan Department of Biology, College of Sciences, Tikrit University, IRAQ.

DOI:

https://doi.org/10.55544/jrasb.3.2.15

Keywords:

Candida, Virulence factor, Fungal, biofilm, cell adhere

Abstract

Candida albicans is a prevalent commensal fungus that inhabits various anatomical regions, including the oropharyngeal cavity, gastrointestinal and vaginal tract, as well as the skin of persons in good condition. C. albicans is present in the normal flora of the microbiota in around 50% of the population. The clinical presentations of Candida species encompass a spectrum of symptoms, spanning from localized. The spectrum of mucocutaneous issues ranges from superficial to invasive disorders that impact many organ systems and present a substantial threat to human life. Disruptions in the normal homeostasis of Candida can be attributed to a range of reasons, encompassing systemic and local factors as well as genetic and environmental influences.

These disruptions ultimately lead to a shift from a state of normal flora to the development of Infections caused by pathogens and opportunistic agents. The initiation and advancement of infection are regulated by the virulence characteristics of Candida, which play a role in the emergence of candidiasis. Oral candidiasis presents with a wide range of symptoms, which can be classified into major and minor types. The gastrointestinal tract is the main reservoir for Candida albicans in the human body. Infection occurs due to an imbalance in the local microbiota, impaired immune function, and damage to the intestinal mucosal barrier. Candidaemia, a term used to describe invasive infections caused by candida, is associated with the presence of Candida albicans in the bloodstream. The mutual relationship remains intact by maintaining a balance between the host immune system and C. albicans virulence factors. This study investigates the virulence traits exhibited by Candida albicans. These components have a significant impact on the development of disorders.

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