Reflection of Vitamins and Mineral Deficiency in General Health Condition: Article Review

Noor Thair Tahir; Mithal R. Alkubaisi; Noor Ghassan Elias; Tawfeeq F. R. Al-Auqbi

doi:10.55544/jrasb.2.6.27

Authors

Noor Thair Tahir National Diabetes Center, Mustansiriyah University, Baghdad, IRAQ. https://orcid.org/0000-0001-9518-6634
Mithal R. Alkubaisi College of Medicine, University of Anbar, Ramadi, IRAQ.
Noor Ghassan Elias Middle Technical University College of Health and Medical Techniquse, Baghdad, IRAQ
Tawfeeq F. R. Al-Auqbi F.I.C.M.S/CM, MD, National Diabetes Center, Mustansiriyah University, Baghdad, IRAQ.

DOI:

https://doi.org/10.55544/jrasb.2.6.27

Keywords:

Vitamin, fat Soluble Vitamins, Water Soluble Vitamins, Minerals, Trace Elements

Abstract

Vitamins are organic substances that humans require in trace amounts. Each plays a distinct part in preserving physical well-being. To increase their supply, some people require supplements; however, this is dependent on their lifestyle and general health. Vitamins are necessary nutrients of the body's healthy growth and operation. Vitamins are divided into two classes: fat and water soluble. Inorganic elements, known as minerals, are derived from food and cannot be produced by the body. Collecting all types of vitamins in a study their sources, functions, excess and deficiency. They have an effective role in the body’s metabolism and immunity and in combating most diseases that affect the human body. Balancing them in moderate concentrations in the human body protects against the risk of contracting many diseases that affect adults and children. Therefore, every individual must take adequate food. It contains all types of vitamins, and in case of deficiency, it is compensated with manufactured vitamins.

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References

ZHANG, Fang Fang, et al. Health effects of vitamin and mineral supplements. bmj, 2020, 369.‏

Venturelli, Sascha, Christian Leischner, Thomas Helling, Markus Burkard, and Luigi Marongiu. 2021. "Vitamins as Possible Cancer Biomarkers: Significance and Limitations" Nutrients 13, no. 11: 3914. https://doi.org/10.3390/nu13113914

Gil Martínez V, Avedillo Salas A, Santander Ballestín S. Vitamin Supplementation and Dementia: A Systematic Review. Nutrients. 2022; 14(5):1033. https://doi.org/10.3390/nu14051033

MARTENS, Pieter-Jan, et al. Vitamin D’s effect on immune function. Nutrients, 2020, 12.5: 1248.‏

Xu, Y., Baylink, D. J., Chen, C. S., Reeves, M. E., Xiao, J., Lacy, C., ... & Cao, H. (2020). The importance of vitamin d metabolism as a potential prophylactic, immunoregulatory and neuroprotective treatment for COVID-19. Journal of translational medicine, 18(1), 1-12.‏

Sinopoli A, Caminada S, Isonne C, Santoro MM, Baccolini V. What Are the Effects of Vitamin A Oral Supplementation in the Prevention and Management of Viral Infections? A Systematic Review of Randomized Clinical Trials. Nutrients. 2022; 14(19):4081. https://doi.org/10.3390/nu14194081.

REDFERN, Chris PF. Vitamin A and its natural derivatives. In: Methods in Enzymology. Academic Press, 2020. p. 1-25.‏

Hernandez, Luis Hector, and Ronald W. Hardy. "Vitamin A functions and requirements in fish." Aquaculture Research 51.8 (2020): 3061-3071.‏

Li, R., Wu, K., Li, Y., Liang, X., Tse, W. K. F., Yang, L., & Lai, K. P. (2020). Revealing the targets and mechanisms of vitamin A in the treatment of COVID-19. Aging (albany NY), 12(15), 15784.‏

ousef S, Colman I, Papadimitropoulos M, Manuel D, Hossain A, Faris M, Wells GA. Vitamin D and Chronic Diseases among First-Generation Immigrants: A Large-Scale Study Using Canadian Health Measures Survey (CHMS) Data. Nutrients. 2022; 14(9):1760. https://doi.org/10.3390/nu14091760.

Guzek D, Kołota A, Lachowicz K, Skolmowska D, Stachoń M, Głąbska D. Effect of Vitamin D Supplementation on Depression in Adults: A Systematic Review of Randomized Controlled Trials (RCTs). Nutrients. 2023; 15(4):951. https://doi.org/10.3390/nu15040951

KOIVISTO, Oona; HANEL, Andrea; CARLBERG, Carsten. Key vitamin D target genes with functions in the immune system. Nutrients, 2020, 12.4: 1140.‏

Martens, Pieter-Jan, et al. "Vitamin D’s effect on immune function." Nutrients 12.5 (2020): 1248.‏

Torquato, Pierangelo, et al. "Vitamin E: nutritional aspects." Molecular nutrition. Academic Press, 2020. 447-485.‏

Traber, Maret G. "Vitamin E: necessary nutrient for neural development and cognitive function." Proceedings of the Nutrition Society 80.3 (2021): 319-326.‏

Sozen, Erdi, Tugce Demirel, and Nesrin Kartal Ozer. "Vitamin E: Regulatory role in the cardiovascular system." Iubmb Life 71.4 (2019): 507-515.‏

Niki, Etsuo. "Lipid oxidation that is, and is not, inhibited by vitamin E: Consideration about physiological functions of vitamin E." Free Radical Biology and Medicine 176 (2021): 1-15.

Card, David John, Renata Gorska, and Dominic Jon Harrington. "Laboratory assessment of vitamin K status." Journal of Clinical Pathology 73.2 (2020): 70-75.‏

Fusaro, M., Gallieni, M., Porta, C., Nickolas, T. L., & Khairallah, P. (2020). Vitamin K effects in human health: new insights beyond bone and cardiovascular health. Journal of nephrology, 33, 239-249.‏

Palmer, C. R., Blekkenhorst, L. C., Lewis, J. R., Ward, N. C., Schultz, C. J., Hodgson, J. M., ... & Sim, M. (2020). Quantifying dietary vitamin K and its link to cardiovascular health: a narrative review. Food & function, 11(4), 2826-2837.‏

Gil Martínez V, Avedillo Salas A, Santander Ballestín S. Vitamin Supplementation and Dementia: A Systematic Review. Nutrients. 2022; 14(5):1033. https://doi.org/10.3390/nu14051033

Fitzpatrick, Teresa B., and Lottie M. Chapman. "The importance of thiamine (vitamin B1) in plant health: From crop yield to biofortification." Journal of Biological Chemistry 295.34 (2020): 12002-12013.‏

Kalyesubula, Mugagga, et al. "High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition." Disease Models & Mechanisms 14.3 (2021): dmm048355.‏

Paez-Hurtado, A. M., C. A. Calderon-Ospina, and M. O. Nava-Mesa. "Mechanisms of action of vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) in pain: a narrative review." Nutritional Neuroscience 26.3 (2023): 235-253.‏

Abdullah, K. M., Arefeen, A., Shamsi, A., Alhumaydhi, F. A., & Naseem, I. (2021). Insight into the In vitro antiglycation and in vivo antidiabetic effects of thiamine: Implications of vitamin B1 in controlling diabetes. ACS omega, 6(19), 12605-12614.‏

Averianova, L. A., Balabanova, L. A., Son, O. M., Podvolotskaya, A. B., & Tekutyeva, L. A. (2020). Production of vitamin B2 (riboflavin) by microorganisms: an overview. Frontiers in Bioengineering and Biotechnology, 8, 1172.‏

HENRIQUES, Bárbara J.; GOMES, Cláudio M. Riboflavin (vitamin B2) and mitochondrial energy. In: Molecular Nutrition. Academic Press, 2020. p. 225-244.‏

Martínez-Limón, A., Calloni, G., Ernst, R., & Vabulas, R. M. (2020). Flavin dependency undermines proteome stability, lipid metabolism and cellular proliferation during vitamin B2 deficiency. Cell death & disease, 11(9), 725.‏

Ehmedah, A., Nedeljkovic, P., Dacic, S., Repac, J., Draskovic-Pavlovic, B., Vučević, D., ... & Nedeljkovic, B. B. (2020). Effect of vitamin B complex treatment on macrophages to schwann cells association during neuroinflammation after peripheral nerve injury. Molecules, 25(22), 5426.‏

Hazim, R. A., Paniagua, A. E., Tang, L., Yang, K., Kim, K. K., Stiles, L., ... & Williams, D. S. (2022). Vitamin B3, nicotinamide, enhances mitochondrial metabolism to promote differentiation of the retinal pigment epithelium. Journal of Biological Chemistry, 298(9).‏

Hrubša, M., Siatka, T., Nejmanová, I., Vopršalová, M., Kujovská Krčmová, L., Matoušová, K., ... & Oemonom. (2022). Biological properties of vitamins of the B-complex, part 1: Vitamins B1, B2, B3, and B5. Nutrients, 14(3), 484.‏

Pietris, James. "The role of NAD+ and nicotinamide (vitamin B3) in glaucoma: a literature review." Journal of Nutritional Science and Vitaminology 68.3 (2022): 151-154.‏

Zhao, Kuo, et al. "Microbial production of vitamin B5: current status and prospects." Critical Reviews in Biotechnology (2022): 1-21.‏

Guo, Jiaxuan, et al. "Metabolic Engineering of Saccharomyces cerevisiae for Vitamin B5 Production." Journal of Agricultural and Food Chemistry (2023).‏

Miallot, Richard, et al. "The vitamin B5/coenzyme A axis: a target for immunomodulation?." European Journal of Immunology (2023): 2350435.‏

Hasan Kadhim, Alaa, Ameer Shamkhi Noor, and Marwa Amer Ali. "The effectiveness of biotin (vitamin b7) added to the diet in improving the efficiency of productivity, and some physiological traits for broiler chickens (ross-308) exposed to oxidative stress." Archives of Razi Institute 77.5 (2022): 1805-1811.‏

Ramamoorthy, Kalidas, et al. "Effect of chronic alcohol exposure on gut vitamin B7 uptake: Involvement of epigenetic mechanisms and effect of alcohol metabolites." American Journal of Physiology-Gastrointestinal and Liver Physiology 321.2 (2021): G123-G133.‏

Corfield, Rocío, et al. "Experimental and modeling approaches applied to the whey proteins and vitamin B9 complexes study." Food Hydrocolloids 142 (2023): 108834.‏

Zeboon, Najat Hussein, and Hayder Abid Al-Razzaq Baqir. "The Effect of Vitamin B9 and E on the Yield and Its Components of the Wheat Crop." IOP Conference Series: Earth and Environmental Science. Vol. 1158. No. 6. IOP Publishing, 2023.‏

Singh, Jagdish. "Vitamin B9 in Dark Green Vegetables: Deficiency Disorders, Bio-Availability, and Fortification Issues." B-Complex Vitamins-Sources, Intakes and Novel Applications. IntechOpen, 2021.‏

Munteanu, Camelia, et al. "E, K, B5, B6, and B9 vitamins and their specific immunological effects evaluated by flow cytometry." Frontiers in Medicine 9 (2023): 1089476.‏

GUÉANT, Jean-Louis; GUÉANT-RODRIGUEZ, Rosa-Maria; ALPERS, David H. Vitamin B12 absorption and malabsorption. In: Vitamins and hormones. Academic Press, 2022. p. 241-274.‏

Markun, S., Gravestock, I., Jäger, L., Rosemann, T., Pichierri, G., & Burgstaller, J. M. (2021). Effects of vitamin B12 supplementation on cognitive function, depressive symptoms, and fatigue: a systematic review, meta-analysis, and meta-regression. Nutrients, 13(3), 923.‏

AZZINI, Elena; RAGUZZINI, Anna; POLITO, Angela. A brief review on vitamin B12 deficiency looking at some case study reports in adults. International Journal of Molecular Sciences, 2021, 22.18: 9694.‏

Boumenna, T., Scott, T. M., Lee, J. S., Palacios, N., & Tucker, K. L. (2021). Folate, vitamin B-12, and cognitive function in the Boston Puerto Rican Health Study. The American Journal of Clinical Nutrition, 113(1), 179-186.‏

Doseděl, M., Jirkovský, E., Macáková, K., Krčmová, L. K., Javorská, L., Pourová, J., ... & OEMONOM. (2021). Vitamin C—sources, physiological role, kinetics, deficiency, use, toxicity, and determination. Nutrients, 13(2), 615.‏

Agarwal, A., Hager, D. N., & Sevransky, J. E. (2021, September). Any role of high-dose vitamin C for septic shock in 2021?. In Seminars in Respiratory and Critical Care Medicine (Vol. 42, No. 05, pp. 672-682). 333 Seventh Avenue, 18th Floor, New York, NY 10001, USA: Thieme Medical Publishers, Inc.

Coker, S. J., Smith-Díaz, C. C., Dyson, R. M., Vissers, M. C., & Berry, M. J. (2022). The epigenetic role of vitamin C in neurodevelopment. International Journal of Molecular Sciences, 23(3), 1208.‏

van Gorkom GNY, Boerenkamp LS, Gijsbers BLMG, van Ojik HH, Wodzig WKWH, Wieten L, Van Elssen CHMJ, Bos GMJ. No Effect of Vitamin C Administration on Neutrophil Recovery in Autologous Stem Cell Transplantation for Myeloma or Lymphoma: A Blinded, Randomized Placebo-Controlled Trial. Nutrients. 2022; 14(22):4784. https://doi.org/10.3390/nu14224784

Sun R, Liu L, Qian T, Zhao M, Che W, Hou X, Xie H, Su Y, Pan H, Li J, et al. Protection of Vitamin C on Oxidative Damage Caused by Long-Term Excess Iodine Exposure in Wistar Rats. Nutrients. 2022; 14(24):5245. https://doi.org/10.3390/nu14245245

Saldaña, Johnny. The coding manual for qualitative researchers. sage, 2021.‏

Weyh, Christopher, et al. "The role of minerals in the optimal functioning of the immune system." Nutrients 14.3 (2022): 644.‏

Silva, Thiago Henrique da, et al. "Effect of injectable trace mineral supplementation on peripheral polymorphonuclear leukocyte function, antioxidant enzymes, health, and performance in dairy cows in semi-arid conditions." Journal of Dairy Science 105.2 (2022): 1649-1660.‏

Orringer, C. E., Blaha, M. J., Blankstein, R., Budoff, M. J., Goldberg, R. B., Gill, E. A., ... & Jacobson, T. A. (2021). The National Lipid Association scientific statement on coronary artery calcium scoring to guide preventive strategies for ASCVD risk reduction. Journal of clinical lipidology, 15(1), 33-60.‏

Jadiya, P., Garbincius, J. F., & Elrod, J. W. (2021). Reappraisal of metabolic dysfunction in neurodegeneration: Focus on mitochondrial function and calcium signaling. Acta neuropathologica communications, 9, 1-31.‏

Patik, J. C., Lennon, S. L., Farquhar, W. B., & Edwards, D. G. (2021). Mechanisms of dietary sodium-induced impairments in endothelial function and potential countermeasures. Nutrients, 13(1), 270.‏

Goodwin, G., & McMahon, S. B. (2021). The physiological function of different voltage-gated sodium channels in pain. Nature Reviews Neuroscience, 22(5), 263-274.‏

Vermeulen, E. A., de Jong, H. B., Blomjous, A. G., Eelderink, C., Hoekstra, T., Elders, P. J., ... & Beulens, J. W. (2021). Magnesium intake and vascular structure and function: the Hoorn Study. European Journal of Nutrition, 1-12.‏

Fiorentini, D., Cappadone, C., Farruggia, G., & Prata, C. (2021). Magnesium: biochemistry, nutrition, detection, and social impact of diseases linked to its deficiency. Nutrients, 13(4), 1136.‏

Li, L., Li, Y., Ye, Y., Guo, R., Wang, A., Zou, G., ... & Ji, X. (2021). Kilogram-scale synthesis and functionalization of carbon dots for superior electrochemical potassium storage. ACS nano, 15(4), 6872-6885.‏

D’Elia, L., Cappuccio, F. P., Masulli, M., La Fata, E., Rendina, D., & Galletti, F. (2023). Effect of potassium supplementation on endothelial function: a systematic review and meta-analysis of intervention studies. Nutrients, 15(4), 853.‏

Yang, Q., Liang, H., Maulu, S., Ge, X., Ren, M., Xie, J., & Xi, B. (2021). Dietary phosphorus affects growth, glucolipid metabolism, antioxidant activity and immune status of juvenile blunt snout bream (Megalobrama amblycephala). Animal Feed Science and Technology, 274, 114896.‏

Nie, W., Wang, B., Gao, J., Guo, Y., & Wang, Z. (2018). Effects of dietary phosphorous supplementation on laying performance, egg quality, bone health and immune responses of laying hens challenged with Escherichia coli lipopolysaccharide. Journal of animal science and biotechnology, 9(1), 1-11.‏

Tonelli, M., Sacks, F., Pfeffer, M., Gao, Z., & Curhan, G. (2005). Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation, 112(17), 2627-2633.‏

Lall, Santosh P. "The minerals." Fish nutrition. Academic Press, 2022. 469-554.‏

Piskin, Elif, et al. "Iron absorption: factors, limitations, and improvement methods." ACS omega 7.24 (2022): 20441-20456.‏

Kawabata, Teruyuki. "Iron-induced oxidative stress in human diseases." Cells 11.14 (2022): 2152.‏

Tiekou Lorinczova, H., Begum, G., Temouri, L., Renshaw, D., & Zariwala, M. G. (2022). Co-Administration of Iron and Bioavailable Curcumin Reduces Levels of Systemic Markers of Inflammation and Oxidative Stress in a Placebo-Controlled Randomised Study. Nutrients, 14(3), 712.‏

Husmann, F. M., Zimmermann, M. B., & Herter-Aeberli, I. (2022). The effect of prebiotics on human iron absorption: a review. Advances in Nutrition, 13(6), 2296-2304.‏

Li, H., Wang, Y., Xu, Y., Wu, K., Lu, X., Qiu, Y., ... & Mao, H. (2022). Association between serum chloride levels with mortality in incident peritoneal dialysis patients. Nutrition, Metabolism and Cardiovascular Diseases, 32(3), 624-631.‏

Jomova, K., Makova, M., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., ... & Valko, M. (2022). Essential metals in health and disease. Chemico-biological interactions, 110173.‏

Chen, L., Min, J., & Wang, F. (2022). Copper homeostasis and cuproptosis in health and disease. Signal transduction and targeted therapy, 7(1), 378.‏

Jäger, S., Cabral, M., Kopp, J. F., Hoffmann, P., Ng, E., Whitfield, J. B., ... & Schulze, M. B. (2022). Blood copper and risk of cardiometabolic diseases: a Mendelian randomization study. Human Molecular Genetics, 31(5), 783-791.‏

Yang, L., Chen, X., Cheng, H., & Zhang, L. (2022). Dietary copper intake and risk of stroke in adults: a case-control study based on National Health and Nutrition Examination Survey 2013–2018. Nutrients, 14(3), 409.‏

Heim‐Ohmayer, P., Freiberger, A., Gedik, M., Beckmann, J., Ziehfreund, S., Zink, A., ... & Schielein, M. C. (2022). The impact of stigmatization of psoriasis, atopic dermatitis and mastocytosis in different areas of life—a qualitative interview study. Skin Health and Disease, 2(4), e62.‏

Chasapis, C. T., Ntoupa, P. S. A., Spiliopoulou, C. A., & Stefanidou, M. E. (2020). Recent aspects of the effects of zinc on human health. Archives of toxicology, 94, 1443-1460.‏

Akram, M., Munir, N., Daniyal, M., Egbuna, C., Găman, M. A., Onyekere, P. F., & Olatunde, A. (2020). Vitamins and Minerals: Types, sources and their functions. Functional Foods and Nutraceuticals: Bioactive Components, Formulations and Innovations, 149-172.‏

Studer, J. M., Schweer, W. P., Gabler, N. K., & Ross, J. W. (2022). Functions of manganese in reproduction. Animal Reproduction Science, 238, 106924.‏

Erikson, K. M., & Aschner, M. (2019). Manganese: its role in disease and health. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic, 19, 253-266.‏

Kabir, Humayun, Ashok Kumar Gupta, and Subhasish Tripathy. "Fluoride and human health: Systematic appraisal of sources, exposures, metabolism, and toxicity." Critical Reviews in Environmental Science and Technology 50.11 (2020): 1116-1193.‏

AGALAKOVA, N. I.; NADEI, O. V. Inorganic fluoride and functions of brain. Critical Reviews in Toxicology, 2020, 50.1: 28-46.‏

Chen, Y., Chen, W., Du, C., Fan, L., Wang, W., Gao, M., ... & Zhang, W. (2019). Iodine nutrition and thyroid function in pregnant women exposed to different iodine sources. Biological Trace Element Research, 190, 52-59.‏

Fuge, R., & Johnson, C. C. (2015). Iodine and human health, the role of environmental geochemistry and diet, a review. Applied Geochemistry, 63, 282-302.‏

Mehdi, Y., Hornick, J. L., Istasse, L., & Dufrasne, I. (2013). Selenium in the environment, metabolism and involvement in body functions. Molecules, 18(3), 3292-3311.‏

Tóth, R. Juhászné, and J. Csapó. "The role of selenium in nutrition–A review." Acta Universitatis Sapientiae, Alimentaria 11.1 (2018): 128-144.‏

Hu, W., Zhao, C., Hu, H., & Yin, S. (2021). Food sources of selenium and its relationship with chronic diseases. Nutrients, 13(5), 1739.‏