Docking Studies of Some Novel Hetrocyclic Compound as Acat Inhibitors: A Meta Analysis

Authors

  • Dr. Aneesa Professor, Department of Pharmaceutical Chemistry, Malla Reddy College of Pharmacy, Affiliated to Osmania University, Hyderabad, INDIA.
  • Roshan Kumar Department of Pharmacology, Dev Bhoomi Institute of Pharmacy and Research, Dehradun-248007, Uttarakhand, INDIA.
  • Purabi Saha Department of Pharmacy, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun-248007, Uttarakhand, INDIA.
  • Keshamma E. Associate Professor, Department of Biochemistry, Maharani Cluster University, Palace Road, Bangalore-560001, INDIA.
  • Parkavi Sachitanadam Project Fellow, Department of Microbiology, Faculty of Science, Annamalai University, Annamalai Nagar, Chidambaram, Tamilnadu - 608002, INDIA.
  • Dr. Muthukumar Subramanian Professor, Department of CSE, SRM Institute of Science & Technology, Tiruchirappalli Campus, (Deemed to be University), Trichy, Tamilnadu - 621105, INDIA.

DOI:

https://doi.org/10.55544/jrasb.1.3.5

Keywords:

Hyperlipidemia, Biological assay, quinoline, docking studies

Abstract

We use molecular modelling and pharmacological testing to identify TCM compounds that may suppress SQS activity. By utilising previously established SQS inhibitors, ten HipHop pharmacophore models were developed. Finally, we used active medicines to explore other potential anti-hyperlipidemia targets in HepG2 cells and establish whether or not the lipid-lowering effect was due to SQS inhibition. As a potential treatment for hyperlipidemia, this research seeks to identify TCM SQS inhibitors. The rings in a heterocyclic compound are each made up of atoms from a different chemical element. Pyridine, thiophene, pyrrole, and furan are the building blocks for quinoline, benzothiophene, indole, benzofuran, benzthiazole, benzimidazole, and benzoxazole, respectively.

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Published

2022-08-31

How to Cite

Aneesa, Kumar, R., Saha, P., E., K., Sachitanadam, P., & Subramanian, M. (2022). Docking Studies of Some Novel Hetrocyclic Compound as Acat Inhibitors: A Meta Analysis. Journal for Research in Applied Sciences and Biotechnology, 1(3), 33–41. https://doi.org/10.55544/jrasb.1.3.5

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